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Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review

ABSTRACT Nasopharyngeal carcinoma typically originates in the fossa of Rosenmüller within the mucosal epithelium directly underlying the lymphatic tissue, and commonly presents clinically with symptoms such as headache, dizziness, and rhinorrhea. In this case study, we describe a 61-year-old man diagnosed with nasopharyngeal carcinoma who underwent radiation therapy with a...
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Rare gynecological entity: malignant cervical PEComa (perivascular epithelioid cell differentiation tumour) - challenges in diagnosis, treatment and surveillance

ABSTRACT Perivascular epithelioid cell tumors constitute a family of mesenchymal tumors characterized by the concomitant expression of melanocytic and muscular markers. Gynecological perivascular epithelioid cell tumors are rare, encompassing about 25% of cases. Studies demonstrate an even rarer occurrence in the uterine cervix. In this article, we report a case...
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Medullary colon carcinoma with microsatellite instability: case report

ABSTRACT Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern. Medullary colon carcinoma is a rare histological variant of colorectal cancer, characterized by a predominantly solid architecture, poorly differentiated or undifferentiated morphology, often...
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Littoral cell splenic angioma, a rare diagnosis of abdominal pain in a child: case report and literature review

ABSTRACT Littoral cell splenic angioma is a rare tumor, especially in the pediatric age group. Patients may experience mild chronic abdominal pain, that does not improve with usual treatments, and is mostly asymptomatic, a challenge for the pediatrics. This article describes the clinical features of a 10-year-old female pediatric patient...
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A 50-year-old male with oropharyngeal squamous cell carcinoma metastatic to hand soft tissue and bone - a case report

ABSTRACT A 50-year-old patient was referred to our service for the investigation of oropharynx cancer and was diagnosed with squamous cell carcinoma. Although there were no signs of distant metastasis, the disease was given as unresectable. The patient was treated with induction chemotherapy followed by chemoradiotherapy. After a trauma episode,...
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Uterine carcinosarcoma with microsatellite instability - does immunotherapy modify the therapeutic scenario? A case report and literature review

ABSTRACT Carcinosarcomas were reclassified by World Health Organization as high-grade uterine carcinomas in 2014. Due to its rare histology, comprising only 5% of uterine carcinomas, there is a small representation of this tumor in studies that evaluate metastatic uterine carcinomas treatment. In 2022, the treatment of metastatic uterine carcinomas has...
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Case report: a rare mediastinal neuroblastoma in an adult associated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

ABSTRACT Neuroblastoma is an embryonic cancer arising from neural crest stem cell and almost exclusively a pediatric neoplasm. In adults, neuroblastoma is rare and presents worse prognosis compared to children. The most common presentation of this neoplasia is a painless abdominal mass. Other signs and symptoms can be related to...
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Small cell neuroendocrine carcinoma of the breast - case series of a common tumour at a rare location

ABSTRACT Small cell neuroendocrine carcinoma of the breast is an uncommon primary tumor of the breast with literature limited to case reports and case series. We hereby report 3 cases of small cell neuroendocrine carcinoma of the breast who presented to our institute. One was an elderly lady and the...
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Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report

ABSTRACT Carcinosarcomas are endometrial neoplasms with malignant epithelial and mesenchymal components. These are rare tumors, corresponding to <5% of uterine cancers. The average age at diagnosis is 65 years and the most characteristic symptom is transvaginal bleeding, common to other uterine tumors. The definitive diagnosis of the lesion is done...
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Non-bacterial thrombotic endocarditis: a case report with favorable evolution and literature review

ABSTRACT Nonbacterial thrombotic endocarditis is an uncommon disease characterized by formation and deposition of sterile fibrin vegetations on heart valves. This condition is more related to states of chronic inflammation, mainly related to malignancy. This report describes the case of a Brazilian woman, 50 years old, smoker, diagnosed with pulmonary...