ABSTRACT Introduction: Abiraterone acetate is widely used for the treatment of prostate cancer. In Brazil, the label dose is not affordable to most patients due to its elevated cost. Mounting data supports the efficacy of abiraterone acetate low-dose with food. Little is known regarding the pattern of prescription of abiraterone...
ABSTRACT Introduction: The implementation of a Psycho-oncology Service depends on institutional, structural, and political factors affecting the availability and quality of this service. Recent events, such as the discontinuation of the Professional Improvement Course, a funding source that supports the training of health professionals, and the ongoing COVID-19 pandemic, have...
ABSTRACT Introduction: Cervical cancer is a major cause of cancer morbidity and mortality in women. Screening for cervical cancer reduces mortality through early detection and treatment. The success of the screening for cervical cancer has been largely attributed to the use of Pap smear (Papanicolaou). The objective of this study...
ABSTRACT Objective: To evaluate the financial impact and effectiveness of a navigation program in patients with colorectal tumors undergoing videolaryngoscopic rectosigmoidectomy. Material and Methods: Retrospective, case-control type study from May 2019 to December 2020 with patients 18 years-old or older; with sigmoid, retosigmoid junction or upper rectal tumors, submitted to...
ABSTRACT Introduction: Malnutrition affects an average of 20-80% of cancer patients, leading to an impaired healing process, increased infection rates and hospital costs, and negative impacts on clinical results. Oral nutritional supplements (ONS) help to increase the patients caloric and protein supplies, promoting recovery of nutritional status. In order to...
ABSTRACT Several formulations of the aromatase inhibitor anastrozole are available in Brazil. We carried out a postmarketing surveillance of the anastrozole (test) formulation in current use at the Brazilian National Cancer Institute (INCA), by comparing anastrozole through plasma concentrations obtained with the test versus the reference formulation. Thirty-three postmenopausal breast...
ABSTRACT Objectives: To report real-world data of a cohort of patients treated with immune-checkpoint inhibitors in Brazil, with focus in immune-related adverse events. Material and Methods: In this retrospective study, we analyzed a cohort of patients with metastatic solid tumors treated at an oncology reference center with at least one dose of...
ABSTRACT Objectives: To evaluate how hormonal therapy can impact breast cancer patients sexual quality of life and compare two widely used therapeutic agents: anastrozole and tamoxifen. Studies so far have evaluated the side effects of such therapy on patients general quality of life, but literature remains scarce regarding the impact it...
Lanolin-based dexpanthenol cream, topical hydrocortisone or observation in the prevention of capecitabine-induced hand-foot syndrome: a phase III trial
ABSTRACT Introduction: The use of capecitabine is associated with hand-foot syndrome (HFS). Since there is anecdotal evidence that lanolin-based creams and topical steroids are useful for the treatment of HFS, we conducted a three- arm phase III trial to compare observation, lanolin-based cream with dexpanthenol (L-D), and topical hydrocortisone in the...
ABSTRACT Introduction: Gallbladder diseases are a well-studied subset of diseases in the Gangetic belt of India. But, the prevalence of gallbladder diseases, both benign and malignant (as a whole subset) has not been studied in Eastern Rajasthan yet. This study aims to provide an epidemiological overview of all histopathologically proven gall...
