Abstract Introduction To assess the sensitivity fluorescent urine cytology induced by 5-aminolevulinic acid (5-ALA) in the diagnosis of bladder cancer and to compare the sensitivity and specificity with currently available markers approved by the United States Food and Drug Administration (FDA), bladder tumour antigen (BTA-TRAK, Bard Diagnostic Sciences, Redmond, WA, United...
Abstract Objective To estimate the incidental radiation dose delivered to the testicles in three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) in rectal cancer patients and its impact on sexual activity using a quality-of-life questionnaire. Materials and Methods The present study included 40 male patients, aged between 25...
Immunohistochemistry and next-generation sequencing for NTRK fusion detection in differentiated thyroid cancer of children, adolescents and young adults
ABSTRACT Introduction: Pan-TRK immunohistochemistry staining can assess the protein expression from NTRK gene fusions. A little is known about its utility in differentiated thyroid cancer samples from children, adolescents, and young adults patients. Objective:Investigate pan-TRKimmunohistochemistry sensitivity and specificity in differentiated thyroid cancer samples from children, adolescents, and young adults patients....
ABSTRACT Introduction: Immunotherapy led to increased survival in advanced non-small cell lung cancer; however, it has also increased treatment costs. In this study, real-world data was used to evaluate the average cost of treatment of patients with lung cancer. Material and Methods: This is a retrospective study that extracted patient-level...
ABSTRACT Objective: To evaluate pharmaceutical bioequivalence between two formulations of 10mg lenalidomide capsules in healthy male subjects under fasting conditions. Material and Methods: An open label, monocentric, randomized, 2x2 crossover study in 32 healthy men under fasting conditions comparing two formulations of lenalidomide capsules. Analyte concentrations in human plasma were...
ABSTRACT Introduction: The studying the quality of life after cancer treatment has become a priority in oncology. Objectives: To evaluate the impact of different treatments for recurrence prostate cancer on quality of life and sexual activity. Material and Methods: Two hundred patients with recurrence prostate cancer after initial treatment were...
ABSTRACT Introduction: Melanoma is the most aggressive type of skin cancer, with a continuous increase in its incidence worldwide. The prognosis of patients is favorable, and the treatment is relatively simple and inexpensive when diagnosed at an early stage. However, early diagnosis requires easy access to the health system. In...
ABSTRACT Despite the absence of data regarding direct costs for healthcare, oncological patients from the Brazilian Unified Public Healthcare System often face significant financial burden due to out-of-pocket costs associated with their treatment. These costs include expenses for transportation, meals, non-covered medications, and the time spent on medical visits, tests,...
ABSTRACT To evaluate the association between the practice of physical exercises, quality of life and clinical outcomes in women diagnosed with and undergoing treatment for breast cancer. Cohort study, following-up women during 6 months after treatment beginning for breast cancer. A total of 149 participants were recruited for convenience in...
ABSTRACT Objectives: To evaluate the outcome of patients with cervical carcinoma submitted to percutaneous nephrostomy due to malignant ureteral obstruction. Material and Methods: Retrospective cohort study with data obtained from medical records of patients diagnosed with cervical carcinoma with renal dysfunction (AKIN = stage 2) undergoing PCN for malignant obstructive...
