Exploring Platinum-Based Treatment Realities: What do Real-World Data Reveal for the Management of Endometrial Cancer in Brazil? – the ECHOS-B Retrospective Study
Abstract Introduction Real-world data on the treatment and outcomes of patients with endometrial cancer, particularly in Latin America, are limited. We herein present the findings of the Endometrial Cancer Health and Clinical Outcomes Study in Brazil (ECHOS-B), which evaluated the treatment patterns for patients with endometrial cancer. Materials and Methods...
Abstract Introduction Myths and false beliefs regarding cancer are widespread among the general population, and they deeply hamper cancer care. It is essential to probe into these misconceptions and to address them for the betterment of treatment outcomes. Materials and Methods The present cross-sectional, observational study was conducted on cancer...
Abstract Spinal metastases are a common complication of systemic malignancies, significantly affecting patients' quality of life and survival. This observational and retrospective study aims to evaluate the epidemiological characteristics of patients undergoing surgery for spinal metastases at A.C. Camargo Cancer Center, as well as their functional status up to 60...
Impact of the COVID-19 Pandemic on Colorectal Cancer Patients at a Major Brazilian Cancer Center: An Increase in Metastatic Patients upon Presentation?
Abstract Introduction The years 2020 and 2021 were peculiar due to the coronavirus disease 2019 (COVID-19) pandemic, which may also have had an impact on people with colorectal cancer (CRC). In the state of Bahia, Brazil, Hospital Aristides Maltez (HAM) is responsible for most of the oncological care, including malignant...
Impact of the Addition of Gemcitabine to Cisplatin-based Chemoradiotherapy on Survival in Locally-Advanced Cervical Cancer: A Retrospective Study in Acre
Abstract Introduction Locally-advanced cervical cancer is prevalent in Brazil's Northern region, with limited therapeutic options. Combining chemotherapy and radiotherapy is the standard, but the role of the addition of gemcitabine to cisplatin-based regimens remains under investigation. Materials and Methods The present retrospective observational cohort study included patients with locally-advanced cervical...
Abstract Introduction Breast cancer is the leading cause of cancer-related deaths among women in Brazil, highlighting the importance of early detection to improve outcomes. Artificial intelligence (AI) has garnered considerable attention for its potential to enhance breast cancer screening by reducing unnecessary exams, minimizing diagnostic errors, and increasing efficiency and...
Abstract Introduction Clinical trials that led to the Food and Drug Administration (FDA) approval of systemic cancer therapies have generally excluded patients with autoimmune disease (AID) due to concerns about increased immune-related adverse events (irAEs), disease flares, and potential reductions in the efficacy of immunotherapies. Objective To evaluate the optimal...
Abstract Objective To analyze the prevalence, characteristics, and management of immediate adverse reactions (ARs) to chemotherapeutic agents in breast cancer patients treated at the National Cancer Institute (Instituto Nacional del Cáncer, INCAN, in Spanish) in Paraguay. Materials and Methods A retrospective, observational, and cross-sectional study was conducted using clinical records...
Abstract This study evaluates the action of Palbociclib in the cell cycle of HPV-negative head and neck squamous cell carcinoma. Initially approved for HER2- and HR + breast cancer. Palbociclib induces cellular senescence, increases the efficacy of Cetuximab, restores p16 function and decreases phosphorylated Rb, suggesting an improvement in survival in both...
Abstract Introduction Cancer is a major social, public health, and economic challenge worldwide, accounting for 1 in 6 deaths globally, according to Globocan 2022. Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there has been a noticeable impact on the provision of services to oncology patients. The present...
