ABSTRACT Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern. Medullary colon carcinoma is a rare histological variant of colorectal cancer, characterized by a predominantly solid architecture, poorly differentiated or undifferentiated morphology, often...
ABSTRACT A systematic review of published articles based on randomized clinical trials was conducted to ascertain the efficacy or perspective of using CAR-T cell therapy for refractory multiple myeloma. The PubMed database was searched with the combination of terms “multiple myeloma”, “refractory multiple myeloma”, “CAR T-cell”, and the PRISMA criteria...
ABSTRACT Introduction: Immunotherapy led to increased survival in advanced non-small cell lung cancer; however, it has also increased treatment costs. In this study, real-world data was used to evaluate the average cost of treatment of patients with lung cancer. Material and Methods: This is a retrospective study that extracted patient-level...
ABSTRACT Objective: To evaluate pharmaceutical bioequivalence between two formulations of 10mg lenalidomide capsules in healthy male subjects under fasting conditions. Material and Methods: An open label, monocentric, randomized, 2x2 crossover study in 32 healthy men under fasting conditions comparing two formulations of lenalidomide capsules. Analyte concentrations in human plasma were...
ABSTRACT Introduction: The studying the quality of life after cancer treatment has become a priority in oncology. Objectives: To evaluate the impact of different treatments for recurrence prostate cancer on quality of life and sexual activity. Material and Methods: Two hundred patients with recurrence prostate cancer after initial treatment were...
ABSTRACT Littoral cell splenic angioma is a rare tumor, especially in the pediatric age group. Patients may experience mild chronic abdominal pain, that does not improve with usual treatments, and is mostly asymptomatic, a challenge for the pediatrics. This article describes the clinical features of a 10-year-old female pediatric patient...
The global landscape of cancer research has undergone a remarkable transformation in recent years. The increasing number of cancer cases worldwide(1) has fueled an unprecedented surge in cancer research publications.(2,3) This explosion of knowledge is underpinned by an equally significant shift towards open access publications, reflecting a commitment to making...
ABSTRACT Introduction: Melanoma is the most aggressive type of skin cancer, with a continuous increase in its incidence worldwide. The prognosis of patients is favorable, and the treatment is relatively simple and inexpensive when diagnosed at an early stage. However, early diagnosis requires easy access to the health system. In...
ABSTRACT Despite the absence of data regarding direct costs for healthcare, oncological patients from the Brazilian Unified Public Healthcare System often face significant financial burden due to out-of-pocket costs associated with their treatment. These costs include expenses for transportation, meals, non-covered medications, and the time spent on medical visits, tests,...
ABSTRACT A 50-year-old patient was referred to our service for the investigation of oropharynx cancer and was diagnosed with squamous cell carcinoma. Although there were no signs of distant metastasis, the disease was given as unresectable. The patient was treated with induction chemotherapy followed by chemoradiotherapy. After a trauma episode,...
