Abstract Introduction Gastric cancer is the fifth most common neoplasm and the fourth leading cause of cancer-related death in the world. The present review aims to offer to the oncologic community the molecular characterization of gastric cancer, the therapeutic innovations and the perspectives for the systemic therapy for gastric cancer. Materials...
Abstract The present review explores the role and impact of second opinions in medical oncology, particularly considering the recent advancements in artificial intelligence (AI) and telemedicine. A comprehensive literature search was conducted, and data from various studies were analyzed, highlighting why patients seek a second opinion, the rates of disagreement...
Abstract Scientific manuscripts are the basis for the transmission of scientific data among physicians in all fields of medicine. To teach young oncologists the skills needed to author a paper, we decided to emulate how experienced clinicians perform this task. The first step is to create a spreadsheet with all...
ABSTRACT Recognition of the molecular basis of gastrointestinal stromal tumors has paved the way for significant breakthroughs in the diagnosis and treatment of this disease as well as positioned gastrointestinal stromal tumors as a framework for the concept of precision oncology in solid tumors. The incorporation of novel targeted agents...
ABSTRACT Borderline ovarian tumors typically exhibit indolent behavior and boast a favorable prognosis; however, a subset of patients experiences disease recurrence and progression to low-grade ovarian carcinoma. The complex biology underlying these phenomena has been illuminated through molecular analyses. KRAS and BRAF mutations have emerged as recurrent findings in borderline...
ABSTRACT Objectives: We propose a preventive and therapeutic assessment program for mucositis in patients with cancer based on a comprehensive review of scientific evidence. Material and Methods: This methodological study, designed as a non-systematic review, entails a thorough review of the scientific evidence on the management of mucositis in patients...
ABSTRACT A systematic review of published articles based on randomized clinical trials was conducted to ascertain the efficacy or perspective of using CAR-T cell therapy for refractory multiple myeloma. The PubMed database was searched with the combination of terms “multiple myeloma”, “refractory multiple myeloma”, “CAR T-cell”, and the PRISMA criteria...
ABSTRACT To report consensus recommendations on the current role of poly(ADP-ribose) polymerase (PARP) inhibitors in the front-line management of patients with epithelial ovarian cancer (EOC) in the healthcare setting of Brazil. The expert panel convened in March 2021 and comprised 20 medical oncologists focus on gynecological oncology. The panel answered...
ABSTRACT Objective: We report the results of a panel of Brazilian experts and provide recommendations for the management of these patients. Material and Methods: The panel convened composed by 28 local opinion leaders, addressed 59 multiple-choice questions taking into account the published scientific literature and their own clinical experience. The...
ABSTRACT The objective of this work is, through a literature review, to promote the debate on personalized medicine and acquire a broad view of the subject and its tools from the perspective of oncology, disseminate the topic, support, and encourage initiatives to implement its technologies in the Brazilian public healthcare...
