Abstract Diffuse large B-cell lymphoma is the most common and aggressive subtype of B-cell non-Hodgkin lymphoma, and its occurrence during pregnancy or the postpartum period is rare. Management in this setting is challenging, due to risks to the mother and infant. We herein report the case of a 37-year-old woman...
Abstract Spondylodiscitis is an uncommon infection affecting the vertebral bodies and surrounding tissues, with an increased incidence in immunosuppressed patients. Back pain is the most common symptom, and early imaging often fails to reveal specific findings. Squamous cell carcinoma (SCC) of the anal canal accounts for 80% of the cases...
Abstract Mucosal melanomas generally arise from mucosal epithelium lining the respiratory, alimentary, and genitourinary tracts and usually carry worse prognosis than cutaneous melanomas. Anorectal melanomas account for 50% of gastrointestinal tract melanomas and 0.3 to 1% of all malignant melanomas. There are no specific treatment guidelines due to the scarcity...
Abstract Diffuse midline gliomas (DMGs), H3K27-altered, are rare and aggressive tumors primarily affecting children, though adult cases occur. These gliomas present significant surgical challenges, and novel techniques are needed to improve outcomes. We present the case of a 53-year-old male with a solid expansive lesion located at T12 to L1,...
Abstract We herein report a case of papillary thyroid carcinoma with an unusual presentation, inside a thyroglossal cyst. An 83-year-old male patient reported a long-standing nodule persisting for over 40 years, with progressive enlargement and periodic dysphonia. The patient underwent total thyroidectomy combined with the Sistrunk procedure. Resection of the...
Abstract Introduction Advances in genomic tools have significantly improved the classification of soft tissue tumors (STTs), enabling the identification of specific subsets characterized by recurrent fusions and genetic alterations involving the Raf-1 proto-oncogene, serine/threonine kinase (RAF1), B-Raf proto-oncogene, serine/threonine kinase (BRAF), and neurotrophic tyrosine receptor kinase (NTRK) genes. The present...
Abstract Crizotinib is a multi-tyrosine kinase inhibitor (mTKI) with efficacy in treating c-ROS oncogene 1-positive non-small cell lung cancer (NSCLC). The association between this TKI and the development of renal cysts is well established, although data on the formation of aseptic abscesses is scarce. We report a case of a...
Abstract Metastatic cervical cancer presents new measures related to the association of biological therapies with conventional treatment that varies according to the presence of biomarkers. Based on a case report, we reviewed therapeutic modalities and updates on the use of concomitant immunobiological and oncological treatments to combat invasive cervical cancer....
Abstract Primary mediastinal large B-cell lymphoma (PMBL) is an uncommon and aggressive subtype of non-Hodgkin large B-cell lymphoma that affects patients in the third and fourth decades of life. The objective of the present report is to describe the case of a male patient admitted to the emergency room with...
Abstract The term giant melanoma was previously characterized as a significantly large melanoma, often exceeding 10 cm in diameter. The present case report presents our experience in managing a giant malignant melanoma in the deltoid region in a 79-year-old patient. Due to the size of the lesion, surgical resection with reconstruction...
