Background: Leptomeningeal carcinomatosis (LC) is associated with poor prognosis among different neoplasia. In breast cancer (BC), data on the activity of systemic therapy in this scenario is scarce. Capecitabine is often selected as a regimen for central nervous system (CNS) metastases from BC in clinical practice. Objective: We aimed to...
Background: Leptomeningeal carcinomatosis (LC) is associated with poor prognosis among different neoplasia. In breast cancer (BC), data on the activity of systemic therapy in this scenario is scarce. Capecitabine is often selected as a regimen for central nervous system (CNS) metastases from BC in clinical practice. Objective: We aimed to...
Introduction: Recently, immunotherapy (IO) has been incorporated into the treatment of triple-negative breast cancer (TNBC). In the metastatic setting, atezolizumab (At) and pembrolizumab (Pemb) had their benefit shown in addition to first-line chemotherapy (CT) for PD-L1 positive TNBC. For localized disease, the addition of Pemb to neoadjuvant CT improved the...
Introduction: Cisplatin-based chemoradiotherapy is the standard of care for the definitive treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) when anatomic preservation is desired. Nonetheless, the equivalence of distinct administration schedules (weekly or every 21 days) and the use of carboplatin as a therapeutic option lacks evidence...
Introduction: In POSEIDON, a Phase 3 study (NCT03164616) of metastatic EGFR/ALK wild-type NSCLC (mNSCLC), first-line tremelimumab + durvalumab + chemotherapy (T+D+CT) demonstrated statistically significant improvements in both progression-free survival (PFS) and overall survival (OS) vs CT alone. Mutations in STK11 and KEAP1 correlate with poor prognosis and are associated with...
Background: Recently, the efficacy of the antibody-drug conjugate, trastuzumab deruxtecan, for HER2-low breast cancer led to an absolute increase of 55% in the proportion of patients who could benefit from this HER2-directed therapy. Among triple- negative breast cancer (TNBC), around 30% of the cases are considered HER2-low. Nevertheless, these data...
Introduction: Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare primary liver malignancy that is more often diagnosed in younger patients in the absence of underlying liver diseases. Given the high incidence of metastatic spread at diagnosis and recurrences after resection, systemic agents have been implemented. However, data on the efficacy of...
Introduction: Platinum-based regimens remain the standard treatment (tx) for advanced ovarian cancer (OC) in Brazil with targeted/immune tx being introduced more recently. Objective: The OCEANIA real-world study evaluated antineoplastic tx use in Brazilian patients with OC over the last 5 years. The time from diagnosis to initial tx, and the...
Introduction: Disease recurrence is common in patients with ovarian cancer (OC), with many requiring multiple lines of therapy (LOTs). Platinum-based therapy remains the cornerstone of treatment for platinum-sensitive patients. The platinum-free interval (PFI) is an important prognostic factor for progression-free survival. Objective: The aim of the OCEANIA real-world study was...
Background: Estrogen receptor (ER) is a remarkable predictive/prognostic biomarker in breast cancer (BC). Tumors with 1-10% cells positive for ER by immunohistochemistry (IHC) are ER-low and, probably, have a more aggressive phenotype. Methods: We retrospectively analyzed consecutive stage I-III BC patients who received neoadjuvant chemotherapy (NAC) at our institution. Luminal...
NEXT-GENERATION SEQUENCING PANEL TO DETECT BIOMARKERS OF HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD): PROFILE OF BRAZILIAN SAMPLES WITH OVARIAN CANCER DIAGNOSIS
The homologous recombination deficiency (HRD) has been used as a biomarker of PARP inhibitors (PARPi) sensitivity in ovarian cancer (OC), especially in high-grade serous (HGS) types. Initially, only likely pathogenic (LPV) and pathogenic variants (PV) in BRCA1/2 were screened to define PARPi eligibility. However, LPV and PV are shown in...
SURVIVAL OUTCOMES FOR GASTROENTERO-PANCREATIC NEUROENDOCRINE TUMORS PATIENTS TREATED WITH 177LU-DOTATATE IN A BRAZILIAN REFERENCE CENTER: A SIX-YEAR FOLLOW-UP EXPERIENCE
Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are the most common NETs primary site. Lutetium-177-DOTATATE (Lu-177) is the standard treatment for patients with grade 1 (G1) or grade 2 (G2) midgut NETs who had disease progression during first-line somatostatin analogue therapy. Objective: Retrospectively evaluate the epidemiological profile, histopathological features, and survival outcomes...
Liver function assessmentis key for managing hepatocellular carcinoma (HCC), because most HCC patients also have a hepatopathy. Child-Pugh score (CP) is widely used and addresses ascites, hepatic encephalopathy, albumin, bilirubin and prothrombin time to classify patients in three groups. However, it relies on non-standardized parameters (ascites, encephalopathy) and extremes of...
Background: Neutropenia is a common and potentially harmful event in oncological patients exposed to cytotoxic chemotherapy. The primary prophylaxis with Recombinant Human Granulocyte Colony Stimulating Factor (G-CSF) is recommended by international guidelines when the anticipated incidence of febrile neutropenia (FN) is ≥ 20%. Yet data of FN of docetaxel more...
Background: Patients (pts) with brain metastases may be referred for brain radiotherapy (BrRT) when exclusive palliative management would be the most appropriate care. Objective: To assess the incidence of the use of BrRT during end-of-life (EOL) care and to evaluate the clinical factors characterizing the pts who underwent BrRT during...
Introduction: Around 10% of Breast Cancer (BC) are linked to genetic predisposition. Recently, Trastuzumab-Deruxtecan showed efficacy among patients with HER2-Low (i.e. HER2 with IHQ 1+, or 2+ with FISH negative). In HER2-Low breast cancer the prevalence of deleterious germline variants is not well characterized. Aim We aim to describe the...
Background: The prognosis of patients (pts) with anaplastic thyroid carcinoma (ATC) is ominous, with overall survival (OS) of 4 mo. in cases with advanced and/or metastatic disease. The possibility of targeted-molecular treatments in those pts with driver alterations, identified by molecular pathology, including next-generation sequencing (NGS), may positively impact this...
Introduction: OncotypeDX is a molecular test of considerable cost, capable of providing prognostic stratification and predicting breast cancer patients who may benefit from the use of adjuvant chemotherapy. Objetive: Describe and correlate clinicopathological charactherists of patients with OncotypeDX score. Method: Data from medical records of women over 18 years diagnosed...
Background: Lack of expression of the tumor suppressor CDX2 is associated with stage II/III colorectal cancer (CRC) poor outcomes. Its potential prognostic and predictive values in metastatic CRC (mCRC), and association with other biomarkers are of interest. Overexpression of the PTGS2 gene encoding cyclooxygenase 2 (COX2) has shown a significantly...
Introduction: Cancer-associated anorexia-cachexia is an insidious syndrome that has an impact on the patient’s quality of life and survival. Mirtazapine has a special therapeutic potential due to its well-known orexigenic action in clinical practice. Objective: To evaluate the effect of mirtazapine compared to megestrol in the treatment of cancer-related anorexia-cachexia...
BACKGROUND: Oxaliplatin is a backbone cytotoxic treatment for mCRC patients, particularly in the front-line setting. In the refractory disease, current treatment options are scarce and with limited efficacy. In Brazil, given limited access to regorafenib or trifluridine and tipiracil, OxRe may be an alternative for fit patients. However, more evidence...
Background: Pathologic Complete Response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer is strongly associated with a favorable prognosis. We evaluated whether there is a correlation between serum levels of circulating tumor DNA (ctDNA) during neoadjuvant therapy with obtaining pCR and detection of residual disease after treatment. Patients and Methods:...
Introduction: Ki67 index is a predictive biomarker for non-metastatic luminal breast cancer treated with hormonal therapy (HT). Recently, although not statistically proven, a discussion of a potential survival improvement with adjuvant abemaciclib in a subgroup of patients with tumors with Ki67 > 20% was raised by the FDA. Data on...
Pathologic complete response (pCR) is an essential prognostic outcome for patients with triple negative breast cancer (TNBC). In this study, we performed a gene expression profile analysis to select candidate predictive biomarkers for pCR in TNBC patients who would receive neoadjuvant chemotherapy (NAC) and identify a profile of patients who...
REAL WORLD DATA ON LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC) PATIENTS IN BRAZIL AND THE IMPACT OF HEALTH INSURANCE TYPE ON CLINICAL OUTCOMES (RELANCE STUDY / LACOG 0118)
Background: Lung cancer is a leading cause of cancer-related death worldwide. Stage III non-small cell lung cancer (NSCLC) represents 20-30% of cancer cases at diagnosis and most recently immunotherapy following chemoradiation improved overall survival in this setting. There is limited data on the current management and outcomes of locally advanced...
Introduction: The American Society of Clinical Oncology (ASCO) proposes clinical practice guidelines recommending the implementation of geriatric assessment (GA) programs. The guidelines establish, at minimum, assessment of patients’ function, comorbidity, fall risk, depression, cognition and nutrition. This intervention should be integrated and intended to guide the development of individualized treatment...
Background: The perioperative use of the FLOT regimen has become the standard-of-care for patients (pts) with ≥ cT2cN0 non-metastatic gastric cancer. Due to its greater toxicity, regimens such as FOLFOX or XELOX have been used as an alternative in clinical practice. However, the use of these regimens perioperatively has never...
Introduction: Inpatients with ovarian cancer may be susceptible to potential drug interactions (PDI) due to exposure to various drugs. Objective: To evaluate the presence of PDI in the prescriptions of hospitalized patients with ovarian cancer and to propose management strategies. Methods: A retrospective, observational study carried out in a period...
Introduction: World Cancer Research Fund International points out prostate cancer as the second most frequent cancer in men worldwide. Radiotherapy is an important curative treatment modality in the management of prostate cancer. However, its use has many undesirable side effects associated with cellular oxidative processes. These side effects related to...
REDUCTION IN THE NEED FOR PHARMACEUTICAL INTERVENTIONS IN MEDICAL PRESCRIPTIONS AFTER ELECTRONIC STANDARDIZATION OF PROTOCOLS PERFORMED BY THE MULTIDISCIPLINARY TEAM IN A PRIVATE CANCER CARE CLINIC IN VITÓRIA-ES
Introduction: Cancer care prescriptions have a high risk of adverse events and that a prescription error may be fatal. Thus, it is extremely important that protocols and prescriptions are standardized and that the entire multidisciplinary team is involved in order to reduce prescription and administration errors. Objective: To identify the...
ESTIMATING RECURRENCES PREVENTED AND COSTS AVOIDED WITH ATEZOLIZUMAB IN EARLY NON-SMALL CELL LUNG CANCER UNDER THE BRAZILIAN SUPPLEMENTARY HEALTH SYSTEM PERSPECTIVE
Introduction: About half of the patients with non-small cell lung cancer (NSCLC) are diagnosed at resectable stages of the disease (stage I-III) and the treatment of choice is curative surgery. However, post-resection recurrences are frequent, with approximately 45% of patients having recurrence within 5 years. In the real world, the...
The treatment of liver tumors, both primary and metastatic, has shown important advances in recent decades. Minimally invasive treatments for early stage liver tumors have gained increasing acceptance due to the consistent body of evidence available in the medical literature. Recently, a new technique was developed and gained notoriety for...
IS COMPREHENSIVE CANCER PANEL BY NEXT-GENERATION SEQUENCING (NGS) MORE EFFICIENT THAN CANCER-SPECIFIC NGS PANEL IN THE MANAGEMENT OF NON-SMALL CELL LUNG CANCER PATIENTS?
Genetic tests play an integral part in the diagnosis, treatment, and prognosis of lung cancer patients. Comprehensive cancer panels using next-generation sequencing (NGS) are gradually becoming the standard tool and replacing the previous approach of single-gene or cancer-specific testing. In this study, we compared the performance of two commercially available...
REAL WORLD EVIDENCE ON THE EFFECTIVENESS OF RIBOCICLIB PLUS AROMATASE INHIBITORS AS FIRST-LINE TREATMENT OF BRAZILIAN PATIENTS WITH HORMONE RECEPTOR-POSITIVE/ HER2-NEGATIVE ADVANCED BREAST CANCER (HR+/HER2–ABC): THE BRASILEEIRA STUDY
Cyclin-dependent kinase (CDK) 4/6 inhibitors are the recommended standard of care for the treatment of HR+/HER2-ABC. Ribociclib (Kisqali®) is the only CDK demonstrating clinically and statistically significant overall survival benefit across all three phase 3 MONALEESA trials. As data on effectiveness are scarce and Latin American populations are underrepresented in...
REPETITIVE PRESENTATIONS OF PHASE II AND III TRIALS INVOLVING SYSTEMIC THERAPIES IN GASTROINTESTINAL (GI) MALIGNANCIES AT INTERNATIONAL MEETINGS IN THE PAST FEW YEARS
Introduction: The American Society of Clinical Oncology (ASCO) and the European Society of Medical Oncology (ESMO) annual meetings as well as their GI dedicated meetings (ASCO GI and ESMO GI) have the premise to accept abstracts for oral presentations that have not been previously presented. Methods: We conducted a review...
CLINICOPATHOLOGICAL PROFILE AND OUTCOME OF ELDERLY EARLY-STAGE BREAST CANCER PATIENTS AGE 75 YEARS OR OLDER: SERIE FROM NATIONAL CANCER INSTITUTE – BRAZIL
Background: Breast cancer patients above 75 years old represent an heterogenous population, often not included in clinical trials. Although treatment decision should not be guided by age but fitness, elderly patients were historically treated distinctly than younger patients. Objective: This study aimed to determine the clinicopathological profile and survival outcomes...
Introduction: Venous thromboembolism (VTE) has a high incidence in cancer patients, being a cause of significant morbidity and mortality in this group. Several factors are associated with a higher risk of thrombotic events, which may be related to the patient, cancer or even the treatments used. OBJECTIVES: To comparatively evaluate...
Introduction: Cancer treatment uses drugs that potentially induce, in certain circumstances, adverse events which are mostly predictable and minimized with the use of supportive drugs. ANVISA provides a notification panel on its website referring to suspected cases of adverse events caused by drugs Purpose The research aims at analyzing the...
Introduction: Breast cancer is the deadliest cancer in Brazilian women; acccording to the estimate of the National Cancer Institute for the year 2021, there were 66,280 cases of breast cancer in Brazil; with an expected risk of 61 cases per 100,000 women. These data highlight the need to identify more...
CHALLENGES FOR THE IDENTIFICATION ON EGFR EXON 20 INSERTION MUTATIONS IN LUNG CANCER: COMPARATIVE ANALYSIS NGS VERSUS QPCR DETECTION METHODS IN A LARGE BRAZILIAN COHORT
Introduction: EGFR exon 20 insertions (ins20) are found in about 2% of non-squamous non-small cell lung cancer (nsNSCLC) patients, representing close to 10% of all EGFR activating mutations. Although there is some heterogeneity, ins20 mutations are not sensitive to 1st to 3rd generation tyrosine kinase inhibitors (TKI). Novel targeted therapy...
Background: Despite the rarity of anal cancer, its incidence is up 30 times higher in HIV-infected patients. Recent studies hypothesize that sulfonyl might have anti-tumor activity. In addition, some Highly Active Antiretroviral Therapies (HAART) contain sulfonyl/sulfonamide, possibly impacting oncologic outcomes in HIV+ patients. Objective: To evaluate the impact of CD4...
Introduction: Although genetic screening of cancer predisposing genes is currently well established for the most common hereditary tumors, there are a number of rare tumors, including sarcomas, which may be associated with hereditary cancer syndromes but whose pathogenic variants frequencies in these genes are still unknown. Aims: Our goal was...
Background: Continued smoking after cancer diagnosis (CSAC) negatively impacts survival. Patients’ (pts) perceptions and awareness of tobacco’s harms are strongly associated with smoking cessation. We hypothesize that pts with cancer who CSAC have an attenuated perception and are less aware of tobacco’s harms than their caregivers. Moreover, we hypothesize that...
Introduction: Although they represent only 1% of all cancers in adults, sarcomas are very aggressive. Objective: To evaluate the improvement in survival of adults diagnosed with soft tissue sarcoma undergoing neoadjuvant chemotherapy (NAC). Methods: Pilot, observational, analytical and retrospective study with patients diagnosed with soft tissue sarcoma, without metastasis, between...
SURVIVAL OUTCOMES AND COST-EFFECTIVENESS OF COMPREHENSIVE GENOMIC PROFILING (CGP) VERSUS SEQUENTIAL SINGLE GENE TESTING (SGT) APPROACH FOR PATIENTS WITH METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER (NSNSCLC) TREATED IN THE REAL-WORLD SETTING
Background: In nsNSCLC, the number and complexity of genomic biomarkers for targeted therapies has increased in recent years, which supported a recommendation for adopting CGP upfront over SGT by many international societies. However, there is no evidence that routine use of CGP improves overall survival (OS) in patients with nsNSCLC....
Introduction: Uterine Carcinosarcomas (UCS) are a rare type of aggressive gynecological tumors composed of an admixture of high-grade carcinomatous and sarcomatous elements. Clinicopathological prognostic factors in UCS, such as sarcoma predominance, are well stablished, but studies that approach the impact of biomarkers in this unusual disease are scarce. The L1-cell...
Introduction: Radiotherapy is a common type of cancer treatment, though patients' feelings about radiotherapy have not been well-studied in Brazil. Objective: The objective of this study was to understand feelings about radiotherapy among cancer patients who had or will complete radiotherapy. Methods: From April to June 2021, a cross-sectional online...
Introduction: The COVID-19 pandemic led to a rapid regulation and structuring of remote working for various activities in society, including medical care. Cancer patients have a greater predisposition to infections and a greater risk of unfavorable outcomes. In addition, several studies have demonstrated cost-saving with remote care. In the other...
IMPACT OF ADJUVANT CHEMOTHERAPY ON SURVIVAL OF PATIENTS WITH RESECTABLE LOCALLY ADVANCED GASTROESOPHAGEAL JUNCTION OR GASTRIC ADENOCARCINOMA SUBMITTED TO PERIOPERATIVE CHEMOTHERAPY
Background: Gastric cancer has a poor prognosis. Perioperative chemotherapy with FLOT (Fluorouracil, Oxaliplatin and Docetaxel) or FOLFOX (Fluorouracil, Oxaliplatin and Leucovorin) are important treatment for resectable locally advanced gastroesophageal junction (GEJ) or gastric adenocarcinoma. However, limited toxicity often causes early discontinuation of treatment. The aim of this study is to...
Introduction: These are rare high grade tumors and there is a lack of survival data and prognostic factors in adults (>18 years) because the population of randomized trials is mostly pediatric. Objective: describe the overall survival in adult patients with Ewing Family Tumors (localized and metastatic) in a retrospective cohort....
Introduction: Merkel cell carcinoma (MCC) is a rare malignant primary skin tumor with neuroendocrine differentiation. Recently, agents blocking the PD-1/PD-L1 pathway have shown objective, durable tumor regressions in patients with advanced solid malignancies. Purpose: This study aimed to describe the clinical, epidemiological and histopathological characteristics of MCC patients, in addition...
EGFR tyrosine kinase inhibitors (TKIs) highlited the beginning of the precision therapy era for NSCLC. In this context, the ex20ins is the third most common EGFR mutation founded. Patients with EGFR ex20ins mutations have not demonstrated the same sensitivity to TKIs (eg. gefitinib and erlotinib) as canonical activating EGFR mutations...
Introduction: Cancer is marked by disruption of circadian rhythms, resulting in an exacerbation of cancer symptom clusters, which may affect the response to treatment and the patient's quality of life. Objective: The main purpose of this study was to investigate basal sAA activity, salivary cortisol and cytokine levels in osteosarcoma...
DIAGNOSTIC ACCURACY OF GALLIUM-68 PROSTATE-SPECIFIC MEMBRANE ANTIGEN POSITRON EMISSION TOMOGRAPHY/ COMPUTERIZED TOMOGRAPHY IN RECURRENT PROSTATE CANCER PATIENTS: A PROSPECTIVE COHORT STUDY
Introduction: Positron emission tomography (PET)/computed tomography (CT) with 68Ga-labeled prostate-specific membrane antigen ligand (68Ga-PSMA) may represent the most promising alternative to multiparametric magnetic resonance imaging (mpMRI) for prostate cancer (PCa) diagnosis. Aim: We evaluate the specificity, sensitivity, diagnostic accuracy, positive predictive value (PPV) and negative predictive value (NPV) in PCa...
Bladder cancer is a complex disease associated with high mortality rates if not treated optimally, where the cytotoxic chemotherapy has been for long time the only standard-of-care treatment for advanced urothelial bladder cancer. Newly FDA (Food and Drug Administration) approved drugs were thought to predict a clinical benefit to patients...
Introduction: Chemotherapy with cisplatin in patients with cervical cancer interferes with quality of life due to nausea and vomiting and is difficult to control even with high-response antiemetic protocols. From this perspective, ginger, in experimental studies, has been shown to be safe to use and has an effect on chemotherapy-induced...
Introduction: The identification of Hereditary Cancer Predisposing Syndromes (HCPS) and its genetic variants in Brazilian populations is an unmet need to improve our Breast Cancer prevention and treatment policies. Cancer patients can benefit from early screening, genetic counseling, preventive procedures and treatment choices. As a multiethnic and continental country, Brazilian...
Introduction: Melanoma is considered the most lethal skin cancer and its incidence has increased during the past decades. About 10% of cases are classifi+B2:J3ed as hereditary melanoma (HM). Several genes have been identified as involved to melanoma susceptibility. CDKN2A and CDK4 were the first high-risk genes discovered. Beyond melanoma, families...
DIFFERENCES IN THE INITIAL PRESENTATION OF ADULT PATIENTS WITH SOFT TISSUE SARCOMAS OF THE EXTREMITIES BETWEEN THE PRIVATE AND PUBLIC HEALTH SYSTEMS IN BRAZIL – A SINGLE-CENTER ANALYSIS
Background: In Brazil, there are scarce data regarding first presentation of patients (pts) with sarcoma. Early diagnosis can reduce radical surgeries, improve quality of life, and prolong survival. We aimed to characterize the clinical staging of pts with soft tissue sarcoma (STS) of the extremities, and evaluate the symptom-to-diagnosis (SD)...
DISTRIBUTION OF SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) IN GENES ASSOCIATED TO REPAIR, DETOXIFICATION, AND IMMUNE SYSTEM IN RURAL WORKERS WITH CANCER TREATED AT A REFERENCE HOSPITAL IN THE STATE OF GOIÁS
Occupational exposure to pesticides can damage the health of farmers, causing a series of diseases, including cancer. In this sense, we carried out a case-control study. The case group consisted of 54 farmers exposed to pesticides who underwent or are undergoing treatment at Hospital Araújo Jorge (HAJ) for head and...
SARS-CoV-2 infection and resulting COVID-19 remains a significant concern for oncology patients, making it important to understand COVID-19 treatment and outcomes within this patient population. More specifically, understanding how the variety of SARS-CoV-2 lineages observed to date during the pandemic have differentially impacted clinical outcomes may help guide care as...
BREAST CANCER PATIENTS WITH UNFAVORABLE NUTRITIONAL PARAMETERS CONSEQUENT TO CHEMOTHERAPY EXPOSURE PRESENT HIGHER SUSCEPTIBILITY TO PROGRESSIVE CLINICAL DISEASE
Background: Breast cancer (BC) is one of the most frequent neoplasms worldwide, contributing to women’s morbimortality. Obesity can affect the efficacy of cancer treatment. However, the mechanisms to explain such an association is not fully understood. Aims: This study aimed to investigate the association between nutritional status and tumor resistance...
EPIDEMIOLOGICAL AND MOLECULAR PROFILE OF NON-SMALL CELL LUNG CANCER BASED ON THE EXPRESSION OF VEGF, ALK AND PD-L1 IN PATIENTS FROM A TOWN IN THE OF RIO GRANDE DO SUL
Introduction: The most recent global estimate indicates that there will be more than 18 million new cases of cancer (INCA, 2018). Patients with advanced non-small cell lung cancer (NSCLC) have a poor prognosis, with a 5-year survival of only 10.7%. The genes involved in carcinogenesis and progression in NSCLC are...
Introduction: Central Nervous System (CNS) tumors are currently defined by the WHO 2021 classification. It presents a wide spectrum of clinically and biologically heterogeneous tumors, which makes the reproducibility of the histopathological diagnosis challenging. DNA methylation profiling has revolutionized diagnostic neuropathology since its implementation. It associates a high throughput methylation...
EPIDEMIOLOGICAL COMPARATIVE CROSS-SECTIONAL STUDY OF THE INCIDENCE OF CENTRAL NERVOUS SYSTEM CANCER CASES IN THE CAPITALS OF BRAZILIAN NORTHERN REGION DURING THE PERIOD FROM 2010 TO 2019
Introduction: Malignant tumors develops due to the growth of cells that, through mutations, acquire proliferative characteristics and resistance to tumor suppressor genes. Tumors of Central Nervous System can be primary or metastatic, with emphasis on brain tumors, which correspond to more than 80% of cases of central nervous system cancers,...
Background: Lung cancer is one of the most prevalent malignancies, with high morbidity and mortality rates. The adenocarcinoma subtype may be related to somatic mutations in EGFR, KRAS, and ALK or PDL-1 expression, among other genetic alterations. Aim: To investigate the frequency of EGFR, KRAS, ALK, and PD-L1 biomarkers in...
REAL WORLD EVIDENCE FOR ONCOLOGICAL OUTCOMES AFTER RADIOTHERAPY OR SURGERY FOR T1A-T1B GLOTTIC SQUAMOUS CELL CARCINOMA: A POPULATION-BASED COHORT STUDY
Purpose: To compare oncological outcomes after surgery (S) or radiotherapy (RT) for T1a-T1b glottic squamous cell carcinoma (T1GSCC) in a population-based cohort study with a propensity score method (PSM). Methods: Patients diagnosed with T1GSCC from 1999 to 2020 were identified from The Fundação Oncocentro de São Paulo database. Only patients...
Background: Anal cancer carcinoma (AC) is an uncommon illness with scarce evidence from low and middle-income nations. We performed a cohort study in a cancer database to evaluate the treatment outcomes of AC treated by chemoradiotherapy (CRT). Methods: Patients with AC staged I-III diagnosed from 1999 to 2020 and treated...
Background: Janus kinase signal transducer and activator of transcription (JAK/STAT) signaling pathway is involved in cell proliferation, angiogenesis, apoptosis inhibition, metastasis and immune suppression. This pathway regulates cutaneous melanoma (CM) development and progression. The JAK1, JAK2 and STAT3 proteins are encoded by polymorphic genes. Objectives: This case-control study aimed to...
Background: Regulatory T lymphocytes (Treg) modulate the destruction of abnormal cells through the binding of tumor necrosis factor (TNF) to tumor necrosis factor receptor 2 (TNFR2) on its surface. The TNFR2 is encoded by the TNFRSF1B polymorphic gene. Healthy individuals may be at distinct risks of CM and CM patients...
Background: Baseline GM composition is associated with pts outcomes in pts with mRCC treated with immune-checkpoint blockade (ICB). We report IMDC risk and tyrosine kinase inhibitors (TKI)'s GM signatures and GM changes during shift during standard mRCC therapies (ICB and TKI). Methods: We prospectively collected fecal samples of all comers...
Purpose: To assess the treatment outcomes and prognostic factors of brainstem glioma (BCG) treated with radiotherapy (RT) or chemoradiation (CHRT) in the last 20 years using a populational-based study. Methods: Patients diagnosed with BSG from 2000-20 were identified from The Fundação Oncocentro de São Paulo database. BSG patients treated with...
Introduction: TP53 is the most mutated gene in lung tumors. However, its prognostic role remains unclear, mainly in admixed populations. Objective: We aimed to evaluate the frequency and clinicopathological impact of TP53 mutations in Brazilian non-small cell lung cancer (NSCLC) patients. MATERIALS AND Methods: We analyzed 446 NSCLC patients. TP53...
Introduction: In the last years, targeted therapies have revolutionized the clinical management of non-small lung cancer (NSCLC) patients as EGFR inhibitors. However, insertions in the exon 20 of the EGFR gene lead to resistance in patients treated with EGFR inhibitors. Thus, new targeted therapies have emerged and could benefit NSCL...
EPIDEMIOLOGICAL PROFILE AND ANALYSIS OF THE TIME INTERVAL BETWEEN SURGICAL AND SYSTEMIC TREATMENTS IN PATIENTS WITH COLON TUMORS IN A PUBLIC HOSPITAL IN MINAS GERAIS: A RETROSPECTIVE COHORT
Introduction: Colorectal cancer is the third isolated cause of new oncological diagnoses in the world, representing 10% of new cases, according to Globocan data(2021). In Brazil, it is the second most prevalent tumor, being the second cause of cancer-related death. In 2020, more than 40,000 new cases were diagnosed. Current...
Introduction: Desmoid tumors (DT) are rare neoplasms with no potential of distant metastasis but with recognized local aggressiveness due to high recurrence rates. Treatment involves systemic treatment, radiation therapy and surgery. The incidence is predominant in young women. There are no consistent data on incidence, prevalence and types of treatment...
Background: Immunotherapy (IO) with anti-PD(L)-1 antibodies have become an integral of the current management of advanced non-small cell lung cancer (aNSCLC). Patients whose tumors have high PD-L1 expression (Tumor Proportion Score - TPS ≥50%) are most likely to respond to these drugs, both as monotherapy or in combination with chemotherapy....
Introduction: Chemotherapy(CT)-induced alopecia is feared side effects by patients (pts). The only method proven effective in preventing hair loss is the use of a scalp cooling (SC) during CT sessions by the contraction of blood vessels reduces the damage of CT to hair follicles. It is an innovative technology that...
CONVERSATIONAL DIGITAL MEDICAL SCREENING THROUGH A FREE MESSAGING APP AS POTENTIAL NEW TOOL TO AVOID BC LATE DIAGNOSIS AT BRAZILIAN PUBLIC HEALTH SERVICE
Introduction: Breast Cancer (BC) delay diagnosis is a national health problem and retrospective analysis suggested that most Brazilian women wait at least 120-160 days from first red flag to BC pathological confirmation. Efficient reference to secondary and tertiary BC specialized unity is crucial to avoid late diagnosis and improve BC...
Introduction: Penile cancer represents only 2% of all types of cancer that affect men in Brazil, but the reality is different in the state of Maranhão. The state has one of the highest numbers of cases in the country and in the world: 6.1 cases per 100,000 inhabitants. This makes...
Introduction: Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), is the most frequently chosen first-line treatment for lung adenocarcinoma patients harboring EGFR activating mutations (del19 and L858R), mainly due to its antineoplastic activity and toxicity profile. However, some patients may present prolonged survival, long-term clinical benefit, and/or absence of disease...
GENE EXPRESSION PROFILES (GEP), INCLUDING IFN-GAMMA AND TUMOR INFLAMATION SIGNATURE (TIS), AS PREDICTORS OF ADVANCED NSCLC RESPONSE TO IMMUNE CHECKPOINT INHIBITORS
Background: Immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced non-small-cell lung cancer (aNSCLC), however, it is still necessary to improve the selection of patients for this therapeutic modality. Gene expression profile (GEP) is a promising way to evolve in this field. The aim of this study was to...
EFFECTIVENESS OF PEMBROLIZUMAB AS MONOTHERAPY OR IN COMBINATION WITH CHEMOTHERAPY FOR RECURRENT OR METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA (RMHNSCC) PATIENTS: A COHORT OF 65 PATIENTS
Pembrolizumab as monotherapy (P) or in combination with chemotherapy (P+C) was stablished as standard of care in first-line therapy for recurrent or metastatic head and neck squamous cell carcinoma (rmHNSCC), following the results of the phase III Keynote-048. After three years of approval by ANVISA, there are still no data...
USE OF FLOT 4 PERIOPERATIVE CHEMOTHERAPY IN PATIENTS WITH GASTRIC CANCER TREATED IN PUBLIC HEALTH SYSTEM: IS IT FEASIBLE AND SAFE EVEN IN NON CANCER CENTERS?
Introduction: The FLOT-4 (fluorouracil, leucovorin, oxaliplatin and docetaxel) perioperative chemotherapy (CT) regimen is consider a standard of care for localized or locally advanced gastric (GC) or gastroesophageal (GEJ) junction adenocarcinoma. Objective: Evaluate the feasibility and tolerance of the use of FLOT-4 perioperative CT regimen in patients (pts) with gastric cancer...
Although breast cancer is the most common tumor type among women, in men it represents about 1% of all cancers identified. There are very few studies related to the genetic causes associated with male breast cancer (MBC). Considering the importance of genetics in the adoption of personalized preventive and treatment...
Breast cancer is the leading cause of cancer death in women in Brazil and has a high survival rate when detected early. Mammography is the only exam whose application in screening programs has proven efficacy in reducing mortality from this pathology. Artificial intelligence has shown significant potential to aid in...
Background: Lung cancer remains the leading cause of cancer death in the world and one of the most lethal cancers in humans. This is a reflection of several factors such as the frequent presence of comorbidities (smoking patients), advanced age and late diagnosis of the disease. In Brazil, up to...
IMMUNOPHENOTYPIC CORRELATES AND OUTCOMES TO FIRST-LINE PEMBROLIZUMAB AMONG PATIENTS AGED 80 YEARS OR OLDER WITH PD-L1-HIGH (≥50%) NON-SMALL CELL LUNG CANCER
Background: Aging is associated with increased levels of systemic inflammation and altered immunosurveillance in cancer. It is currently unclear whether older age correlates with a distinct immunophenotype or impacts clinical outcomes to first-line pembrolizumab in patients with advanced non-small cell lung cancer (NSCLC) and a PD-L1 TPS of ≥50%. Patients...
Background: Breast cancer has a strong epidemiological impact. Approximately 20% are HER-2 positive. In the metastatic scenario, first-line treatment was consolidated with the CLEOPATRA study and second-line treatment with trastuzumab-entamsine (T-DM1) with the EMILIA study. But the third line is still challenging. Objectives: To compare the Overall Survival (OS) of...
Background: This study characterized and compared the molecular profiles of CX3C chemokine receptor 1 (CX3CR1, a marker of T-cell differentiation), Toll-like receptor 4 (TLR4)-mediated interferon signaling pathway and immune checkpoints in the different histological stages of non-muscle invasive bladder cancer (NMIBC), aiming the adaptation of these biomarkers as a criterion...
CX3CR1+CD8+ T CELLS, IMMUNE CHECKPOINTS AND TOLL-LIKE RECEPTOR 4-MEDI-ATED INTERFERON SIGNALING PATHWAY ARE CRITICAL IN ANTITUMOR EFFICACY OF ONCOTHERAD IMMUNOTHERAPY IN THE NON-MUSCLE INVASIVE BLADDER CANCER
Authors: Wagner José Fávaro / Center of Immunotherapy and Inflammatory Diseases, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Bianca Ribeiro de Souza / Center of Immunotherapy and Inflammatory Diseases, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Juliana Mattoso Gonçalves / Center of Immunotherapy and Inflammatory Diseases, University of...
INCIDENCE, CLINICAL AND MORPHOOGICAL DESCRIPTION OF MALIGNANT LYMPHOPROLIFERATIVE DISEASES IN PATIENTS WITH VERTICAL TRANSMISSION OF HIV IN RIO DE JANEIRO IN THE POST CART ERA: A MULTICENTER STUDY
With combined antiretroviral therapy (cART), AIDS became a chronic disease, increasing both survival of patients and prevalence of the infection in children. Incidence of cancer in children and teenagers infected with HIV is 5 to 8 times superior when compared to non-infected ones, being non-Hodgkin ymphoma (NHL) the most common...
DOCETAXEL AND CISPLATIN (TP) IN COMPARISON TO DOCETAXEL, CISPLATIN AND FLUOROURACIL (TPF) FOR THE INDUCTION THERAPY OF LOCALLY ADVANCED HEAD AND NECK SQUAMOUS CELL CARCINOMA
Introduction: Locally advanced head and neck squamous cell carcinoma (LAHNSCC) treatment involves disease control with maximum anatomical preservation, for which multimodal therapy with induction chemotherapy may be indicated. The combination of docetaxel, cisplatin and infusional fluorouracil (TPF) is the standard approach. However, some prospective single arm trials have shown activity...
PERIOPERATIVE CHEMOTHERAPY VERSUS UPFRONT SURGERY WITH ADJUVANT CHEMOTHERAPY IN GASTRIC AND ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA, A RETROSPECTIVE TRIAL
Introduction: gastric cancer represents a common cause of cancer death worldwide. Adenocarcinoma accounts for more than 95% of all gastric malignancies. Are estimated more than 26.000 new cases in United States (US) per year (2021), with 11.000 deaths. In Brazil it represents the 4th most incident cancer in men and...
Background: The rise of Immune Checkpoint Inhibitors (ICI) as a cancer treatment has been followed by the increase of cardiotoxicity events reports. Retrospective studies with anthracycline revealed a relationship between increased myocardial 18F-FDG uptake (MGU) and a slight drop in Left Ventricular Ejection Fraction values, suggesting that this may be...
Introduction: Advances in genetic research have enabled the recognition of new cancer predisposing genes (CPG). Studies have shown that up to 10% of patients (pts) with neuroendocrine neoplasms (NEN) have a hereditary cancer syndrome, with the most common being multiple endocrine neoplasia types I and II and von Hippel Lindau...
Introduction: Bladder cancer (BdC) is primarily seen among older individuals, with a median age at diagnosis of 73 years(y). However, the older population is usually underrepresented in clinical trials (CT). This study aimed to evaluate the inclusion of older patients (OP) in BdC CT. Methods: A systematic search of PUBMED,...
Introduction: Treatments based on fluoropyrimidines, represented by 5-fluorouracil (5-FU) and its oral prodrugs, have been widely used in several malignant cancer, including gastrointestinal cancer. However, more than 30% of patients develop severe toxicity and approximately 1% develop lethal toxicity. Identification of new polymorphisms in genes involved in the 5-FU metabolism...
PANCREATIC ADVANCED ADENOCARCINOMA: EFFECTIVENESS OF FOLFIRINOX CHEMOTHERAPY VERSUS PACLITAXEL NANOPARTICULATE + GEMCITABINE FOR CONVERSION TO RESECABILITY AND OVERALL SURVIVAL
Introduction: Pancreatic cancer is responsible for 2% of cancers diagnosed in Brazil, whoseprevalent histopathological subtype is adenocarcinoma. In borderline disease, the use of conversion chemotherapy aims at complete resection and extending overall survival (OS). In this context, the following protocols can be performed: Folfirinox (FFX) or Paclitaxel nanoparticulate with Gemcitabine...
STATISTICS OF PAPERS PRESENTED AT ASCO: WHAT ARE THE CHARACTERISTICS OF PHASE 2 AND PHASE 3 TRIALS IN BREAST CANCER PRESENTED AT ASCO IN THE PAST 5 YEARS?
Introduction: The ASCO Annual Meeting is the largest and most important clinical oncology conference in the world. Each year, more than 30,000 healthcare professionals attend and an average of 4,200 abstracts are presented, providing a source of publications and knowledge for the oncology community. GOALS: Analyse the characteristics of phase...
