ABSTRACT Introduction: Malignant neoplasms are a major public health problem, being the second leading cause of death in the world. In 2012, the Ministry of Health (BR) instituted Law No. 12,732, which grants cancer patients the right to obtain, from the anatomopathological diagnosis, access to the first treatment in the Brazilian...
ABSTRACT Patient Reported Outcomes (PROs) are a report that comes from patients on a specific subject, describing how they feel about a condition or therapy. The term includes a range of constructions and methodology and can cover concepts such as symptoms to physical assessment, well-being and social involvement. The process...
ABSTRACT Objective:This study analyzed the association between xenobiotic metabolism and DNA repair gene polymorphisms and overall survival (OS) and disease-free survival (DFS) in patients diagnosed with HNSCC in a Brazilian population. Methods: Retrospective study included 91 patients with a confirmed diagnosis of HNSCC. A total of 7 genes were analyzed: XRCC1,...
ABSTRACT Cervical cancer is the second most common cancer among women worldwide and also in Angola. Its highest incidence occurs in women between 45 and 55 years of age; the main etymological factor is the infection with human papilloma virus (HPV), whose DNA is detectable in more than 99% of...
ABSTRACT We report a case of a patient with metastatic colon cancer without central nervous system metastases who presented with a spontaneous intraparenchymal hematoma using bevacizumab, without coagulation disorders or metastatic cells in the pathological examination. Bevacizumab is a monoclonal antibody against vascular endothelial growth factor (VEGF) that inhibits binding...
ABSTRACT Case report of three patients with inflammatory bowel disease who underwent treatment with biology therapy and developed respectively: non-Hodgkins lymphoma, colorectal adenocarcinoma, and cholangiocarcinoma after long-term follow-up. They demonstrated that data are currently inconclusive about the development of long-term anti-TNF neoplasias.
ABSTRACT Introduction: Primary breast melanoma is a rare condition and most of cases are associated with melanoma overlying the skin of the breast or metastatic disease site. Primary breast parenchyma melanoma (PBPM) is extremely uncommon with only seven cases reported in the last four decades. Case report: A 44-year-old woman presented with...
ABSTRACT Introduction:Many limitations in the Brazilian public health system make the patient's journey with HER2+ breast cancer and the access to better treatments hard. In the scenery in which all the economic resources of the country are limited, the right incorporation of the health technologies proves to be a challenge....
ABSTRACT Cancer is the main public health problem in Brazil and the world, and if the National Oncological Care Policy is not modified, cancer will become the leading cause of death in the country in 2029. However, the guidelines of the Ministry of Education do not have oncology as a...
ABSTRACT Background and Objective: Cancer is expected to be the leading cause of death in Brazil by 2030. This scenario demands that health professionals, especially physicians, should be able to implement primary prevention, early detection and cancer patient support. Despite this unquestionable need, there is a clear gap in Oncology training...
