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2021 | III Semana Brasileira da Oncologia

Editorial

Dear Colleagues, In face of a challenge year for the health all around our country and world, cancer treatment multidisciplinary approach become even more important. Therefore, follow a big amount and speed of information currently established in oncology, suit an assignment increasingly hard and complex. In this context, the Sociedade...
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EFFICACY AND SAFETY OF TOTAL NEOADJUVANT THERAPY (TNT) REGIMENS IN PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER (LARC) TREATED IN SALVADOR-BA A RETROSPECTIVE COHORT STUDY

Protásio, Bruno M.
Introduction: Based on OPRA and RAPIDO trials, Total Neoadjuvant Therapy (TNT) has become an option in the treatment of locally advanced rectal cancer (LARC). Objective: To evaluate the efficacy and safety of TNT regimens in a population with LARC treated in the community. Methods: Between May 2020 and May 2021...
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COMPARATIVE ANALYSIS OF CHEMO-THERAPEUTIC AGENTS IN THE TREATMENT OF LOW-RISK GESTATIONAL TRO-PHOBLASTIC NEOPLASIA

Oliveira, João Vitor Matos De
Introduction: Gestational trophoblastic neoplasia (GTN) is a rare malignant disease that can develop after a molar or non-molar pregnancy and it is diagnosed by the abnormal regression curve of ß-hCG. Patients with low-risk GTN obtain a risk score < 7, according to the World Health Organization risk score, as used...
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TRENDS IN LUNG CANCER MORBIMORTALITY IN BRAZIL

Oliveira, Nina Victoria Menezes De Melo De
Introduction: Lung cancer (LC) is the third most frequent type of cancer in Brazil and the main cause of mortality from cancer. It is considered a challenge for public health, because its signs and symptoms usually manifest in advanced stages and is mistaken with other pulmonary pathologies. Objective: To present...
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THE ROLE OF PURINERGIC SIGNALING IN THE PATHOPHYSIOLOGY OF CERVICAL CANCER

Pfaffenzeller, Marta Schmidt
Introduction: Cervical Cancer (CeCa) is the fourth most common type of cancer incidence in the world female population. There are numerous different factors involved in this type of cancer, including intrinsic factors related to the inflammatory process, such as extracellular nucleotides and adenosine - compounds of the purinergic system. Objective:...
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NEUROENDOCRINE CARCINOMA OF SMALL CELLS OF THE UTERUS: A CASE REPORT OF A RARE TUMOR

Souza, Hebert Cristian
Case presentation: VSP, female, 34 years old, married, was admitted to the service in July 2020, with severe metrorrhagia, pain in the lower abdomen and anemic manifestations, in the last 3 months with the need for transfusion of blood components. Pelvic MRI on 07/03/ /2020 with a voluminous expansive lesion...
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SEXUAL LIFE QUALITY IN PATIENTS WITH CERVICAL CARCINOMA IN SITU: A CONTROL GROUP STUDY

Franciosi, Maria Luiza Mukai
Introduction: Cervical cancer is the fourth most prevalent cancer in women worldwide. The Human papillomavirus (HPV) is the principal risk factor for high-grade intraepithelial lesions development. Its diagnosis could affect the quality of sexual life in women. In this way, the patients relate symptoms and signs, such as dyspareunia, bleeding,...
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CLINICAL AND SOCIODEMOGRAPHIC PROFILE OF PATIENTS WITH CUTANEOUS MELANOMA TREATED AT A PUBLIC ONCOLOGY REFERRAL HOSPITAL IN FLORIANOPOLIS, FROM 2013 TO 2017

Silveira, Matheus Beltrami
Introduction: Cutaneous melanoma is the most lethal skin cancer and its incidence has significantly increased in recent years. In particular, Florianópolis is the Brazilian capital with the highest incidence of the disease. Objective: To investigate the clinical and sociodemographic profile of patients with cutaneous melanoma treated at a public oncology...
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THE INFLUENCE OF SPIRITUAL WELL-BEING AND DEPRESSION ON THE PERCEPTION OF PAIN IN PATIENTS WITH METASTATIC BREAST CANCER

Brandes, Samantha
Introduction: Breast cancer is the second most common cancer in the world and the most prevalent among women. It is known that 20% to 50% of patients with breast cancer complain of pain, a number that increases to 90% in metastatic patients. The frequency of pain increases as the disease...
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Risk of hepatocellular carcinoma recurrence after the use of direct-acting antivirals in the treatment of hepatitis C: a systematic review and metanalysis

Cuba, Jefferson Wrublack
Introduction: Hepatitis C is associated with the development of hepatocellular carcinoma. The therapeutic regimen based on interferon has been replaced by direct-acting antivirals to treat HCV infection. However, recent studies have shown an unexpected increase in hepatocellular carcinoma recurrence in patients treated with this new regimen of antivirals. Objective: To...
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HOSPITALIZATIONS FOR MALIGNANT STOMACH NEOPLASM FROM 2010 TO 2020

Santos, Michele Almeida Dos
Introduction: Stomach cancer can be considered a major public health problem, considering that it is the third most common neoplasm in males and the fifth most common in females. It does not have a specific etiology, and therefore its diagnosis becomes a little late, with a high mortality rate and...
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DEMOGRAPHIC ANALYSIS OF COLON MALIGNANCY BETWEEN 2010 AND 2020 IN BRAZIL

Vale, Ana Rafaela Soares Do
Introduction: The colonic neoplasm is a frequent disease by sporadic factors or genetics factors. It is considered the main cancer in the gastrointestinal system, with a higher prevalence in individuals older than 50 years, in male sex and in African descendents. The earlier detection of adenomatous polyp is a key...
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Evolution of cancer patients with confirmed diagnosis of covid 19 in a High Complexity Oncology Reference Center

Cartaxo, Wilka Valente A.
Introduction: The new coronavirus was first thought to cause viral pneumonia and was discovered as a viral manifestation in the city of Wuhan, in December 2019, in China. Afterwards, it was discovered that it can cause the severe acute respiratory syndrome coronavirus 2 (SARS -COV - 2). This name is...
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PSYCHIC RISK IN ONCOLOGICAL PATIENTS IN GENERAL HOSPITAL: WHAT CHANGED BEFORE AND DURING THE PANDEMIC?

Borges, Mayara
Introduction: The presence of the first cases of COVID-19 to the institution brought uncertainties, although the need to pay attention to the care of cancer patients and their psychological suffering[5], understanding that cancer disease implies changes, raising doubts, insecurities, high prevalence of anxiety, depression and distress.[2] Thus, studies propose psychological...
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MULTIDISCIPLINARY PATIENT CARE AT THE BEGINNING OF SYSTEMIC CANCER TREATMENT

Wanke, Thamires
Introduction: The diagnosis of cancer generates impacts for the patient and family during the treatment, causing suffering from the perspective of physical and emotional changes, given discomfort, pain, dependence, loss of self-esteem etc[1-4]. In turn, the use of chemotherapy is associated with adverse events and impairments in quality of life,...
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TESTICULAR GERM CELL TUMORS: INSIGHTS FROM EPITHELIAL-MESENCHYMAL TRANSITION

Lopes, Luis Fernando
Introduction: Germ cell tumors (GCTs) are benign or malignant neoplasms derived from germ cells that can occur in gonadal or extragonadal sites, representing 3,3% of malignant tumors. Testicular GCTs (TGCTs) are organized into two main histological groups, known as seminoma and non-seminoma germ cell tumors (NSGCTs). Seminoma GCTs are made...
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ADVANCE DIRECTIVES AND CANCER: MEDICAL ONCOLOGY PRACTICE IN BRAZIL

Nunes, Rui
Introduction: The prevalence of Advance Directives (AD) in cancer patients varies widely between countries, reaching 88% in the United States, 53% in Canada and 23% in Germany. Studies involving cancer patients since the 1990s have shown a very low preference (9% in the United States and 2% in Canada) among...
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PROSTATE MALIGNANT NEOPLASMS: MORTALITY AND EPIDEMIOLOGICAL PROFILE IN BAHIA, 2015-2020

Andrade, Beatriz Cristina De Moura
Introduction: Prostate adenocarcinoma is the second leading cause of neoplasm death among men in the world. In Brazil, it has been estimated for the triennio 2020-2022 about 66.000 new cases, although, the National Cancer Institute does not recommend systematic screening. Therefore, it is necessary to evaluate the most relevant epidemiologic...
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IMMUNOTHERAPY TREATMENT IN ADVANCED MELANOMA IN THE PUBLIC HEALTH SYSTEM IN ONCOLOGY REFERENCE HOSPITAL IN SOUTHERN BRAZIL

Mireski, Raquel
Introduction: Cutaneous melanoma had an incidence of 324.535 new cases worldwide in 2020 and caused 57.043 deaths. The pathophysiology of melanoma is complex, and the development of new therapies has changed the survival and life quality of patients with advanced disease. Immunotherapy, especially with anti-PD-1 immune checkpoint inhibitors, has shown...
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CASE REPORT: PEDIATRIC PULMONARY NEUROENDOCRINE CARCINOID TUMOR

Gonçalves, Lucas Ferreira
Case presentation: Patient, 12 years old, leucoderma, from Governador Valadares, MG. It evolved for 6 days with fever, dyspnea and chest pain. A chest radiography was requested, which showed a nodular image on the right hilar topography. A tomography was performed, which showed oval and hypodense mass, with regular contours...
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ASSESMENT OF SKIN CANCER INCIDENCE IN SCREENING PROGRAM IN ESPIRITO SANTO (BRAZIL)

Sarmenghi, Ícaro Pratti
Introduction: Skin cancer is the most common malignant neoplasm in the Brazilian population, representing 30% of these diagnoses. It can be classified as non-melanoma skin cancer (NMSC) and melanoma skin cancer (MSK). Concerning to NMSC, basal cell carcinoma (BCC), the most common one and with the best prognosis, and squamous...
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INFLUENCE OF CLINICAL AND ANATOMO-PATHOLOGICAL FACTORS ON THE SURVIVAL OF PATIENTS WITH CUTANEOUS MELANOMA TREATED IN THE WESTERN REGION OF SANTA CATARINA

Soares, Gilnei Fitler
Introduction: Melanoma is a skin cancer that, despite being the least frequent, has the highest mortality and morbidity rate. There are several factors that influence the survival of affected patients and are related to the characteristics of the population studied. Objective: Analyze the main factors that influence the survival rate...
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NEOPLASMS AS THE MAIN BASIC CAUSE OF MORTALITY AND POTENTIAL YEARS OF LIFE LOST AMONG PHYSICIANS OF ESPIRITO SANTO FROM 2006 TO 2015

Sarmenghi, Ícaro Pratti
Introduction: Evidences demonstrate the high and early mortality of physicians in relation to the general population. In addition to problems related to the working hours, an important factor is the self-confidence between the doctors in relation to their own health and the adoption of self-medication not supported by diagnosed teststings...
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ANALYSIS OF CD80 AND CD86-EXPRESSING B LYMPHOCYTE LEVELS IN THE BLOOD OF WOMEN WITH LOCALLY ADVANCED TRIPLE NEGATIVE BREAST CANCER

Kerstenetzky, Maria Eduarda Borges
Introduction: Breast Cancer was the second most common malignant neoplasm and the leading cause of cancer-related death in women worldwide in 2020;it can be classified according to the immunohistochemical pattern in four main tumor subtypes, with triple negative breast cancer (TNBC) being the most aggressive subtype with the worst prognosis....
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18F-FDG-PET/CT RESPONSE ASSESSMENT IN PATIENTS WITH ADVANCED MELANOMA TREATED WITH COMBINATION OF LOW-DOSE IPILIMUMAB AND ANTI-PD1: A REAL WORLD EXPERIENCE

Liz, Caio Dabbous De
Introduction: Combination therapy with anti-PD1 and low-dose ipilimumab has shown reduced rate of immune-related adverse effects compared with standard dose used in the Checkmates studies 067 and 204. However, the discussion whether low-dose ipilimumab may hamper the response rate in advanced melanoma is still open. Objective: Evaluation of efficacy and...
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ACCESS TO ONCOLOGIC SERVICES IN THE CONTEXT OF THE BRAZILIAN NATIONAL HEALTH SYSTEM: ECOLOGICAL STUDY

Oliveira, Anderson Varjão
Introduction: Cancer represents a public health problem in the world and is among the four main causes of premature death, before 70 years of age. The extended access to health services for cancer patients is a consequence of the expansion of oncologic care, but some situations can affect this expansion...
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SCIENTIFIC EVIDENCE ON THE USE OF METRONIDAZOLE AGAINST THE ODOR OF TUMOR WOUNDS

Buono, Paula Paixão
Results: In view of the analysis, the efficacy and safety of the topical use of metronidazole gel 0.7% for the management of bad odor in malignant tumors was evidenced, with a topical application being done 2 times/day for 14 days, bringing success in the treatment. In another study developed with...
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PREVALENCE OF ANTICIPATORY NAUSEA AND VOMITING IN CANCER PATIENTS EXPOSED TO HIGHLY EMETOGENIC CHEMOTHERAPY

Alves, Rafaela De Brito
Introduction: Anticipatory nausea (AN) and vomiting are unpleasant symptoms observed in anticipation of chemotherapy regimens. It is best described as a learned response throw classical conditioning when one or more distinctive features of the chemotherapy clinic (conditioned stimuli) associated with the administration of emetogenic chemotherapy (unconditioned stimuli) trigger the emetogenic...
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ARTIFICIAL INTELLIGENCE FOR MELANOMA SCREENING: DEVELOPING A SMARTPHONE APP

Bourckhardt, Taina Da Rosa
Introduction: Melanoma is a complex and heterogeneous cancer originating from melanocytes and most commonly found in its cutaneous form. Despite the increasing incidence and high lethality due to the potential for metastasis, it has a good prognosis if detected at an early stage. In current medical practice, suspicious lesions are...
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ANALYSIS OF THE SCIENTIFIC EVIDENCE OF THE EFFECTIVENESS OF IMMUNOMODULATION IN NEOPLASMS: A SYSTEMATIC REVIEW

Guerra, Bárbara Lima
Introduction: Immunomodulators are drugs used for the treatment of diseases, whose main objective is to stimulate or reduce the immune response. Accordingly, the increasing use of multiple immunomodulatory agents is occurring for cancer therapies due to the possibility of controlling the growth and development of these tumors by activating the...
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Clinical predictors of patients with hepatocellular carcinoma: a systematic review

Guerra, Bárbara Lima
Introduction: Hepatocellular carcinoma is among the most incidente cancers in adults, representing worldwide the fifth most common type of cancer in men and the seventh in women, with an estimated 841,000 new cases reported in 2018. Moreover, it is considered a major global health challenge because it has a high...
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Case Report and Literature Review: Neuroendocrine Thyroid Carcinoma with Negative Calcitonin

Castro, Tadeu Avila
Case presentation: 60 years old, male, presented right vocal cord injury; biopsy showed undifferentiated neoplasia and immunohistochemistry as poorly differentiated Neuroendocrine Carcinoma (AE1/AE3, thyroid transcription factor 1 and Sinaptofisin positive; KI-67 90%). Neck examination revealed mass in the right thyroid, hardened and with palpable lymph nodes. Cervical tomography with expansive...
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INTERPLAY BETWEEN MUTATIONAL PROFILE AND TMB ON OVERALL SURVIVAL: A POSTHOC ANALYSIS OF 1,662 METASTATIC PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS

Awni, Beatriz Mendes
Introduction: Tumor mutational burden (TMB) represents the total of mutations in the tumor genome, and TMB≥10mut/ Mb received FDA agnostic approval for pembrolizumab use. Objective: A more integrative view of this biomarker is needed to select better candidates to immune checkpoint inhibitors (ICI). Methods: We performed a posthoc analysis of...
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LIGHT EMITTING DIODE FOR THE TREATMENT OF GENITOURINARY SYNDROME OF MENOPAUSE IN BREAST CANCER SURVIVORS (LED-CA): STUDY PROTOCOL FOR A DOUBLE BLINDED TRIAL

Pavie, Maria
Introduction: Genitourinary Syndrome of Menopause (GSM) after breast cancer occurs associated with long-term side effects of cancer treatment. Light-Emitting Diode (LED) is an instrument potentially capable of stimulate the epithelium, and so mitigate symptoms, with low side-effects and lower cost than other energy-based devices. Objective: This study aims to analyze...
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PROSTATE CANCER AND SPIRITUALITY – A SYSTEMATIC REVIEW

Neves, Nathália Meneses
Introduction: Prostate cancer is the second most diagnosed cancer and the sixth leading cause of cancer death among men worldwide. The diagnosis, treatment and sequels of cancer are relevant sources of stress, conflicts, and suffering. In this context spirituality may be a positive coping element. However, studies involving the correlation...
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ACCESS POLICIES FOR ONCOLOGICAL HEALTH SERVICES IN BRAZIL: AN ECOLOGICAL STUDY

Menck, Joane Caroline
Introduction: Cancer is a group of diseases of multifactorial origin with increasing incidence and mortality. The Brazilian Unified Health System (SUS) subsidizes most oncological treatments, but the supply and access to health services in Brazil is still limited and has high discrepancies in the availability of highly complex oncological services...
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ROLE OF ONCOTHERAD NANO-IMMNOTHERAPY IN BCG-UNRESPONSIVE NON-MUSCLE INVASIVE BLADDER CANCER: AN OPEN-LABEL AND SINGLE-ARM PHASE 1/2 STUDY

Fávaro, Wagner José
Introduction: Current treatment for high-risk non-muscle-invasive bladder cancer (HRNMIBC) involves Bacillus Calmette-Guérin (BCG) therapy, but treatment options are limited for patients with recurrent or BCG-unresponsive disease. The synthetic nanocompound, Biological Response Modifier -Inorganic Phosphate Complex 1, registered as OncoTherad, leads to the distinct stimulation of the immune system mediated by...
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INCIDENCE OF ADVANCED-STAGE CANCER ELIGIBLE FOR SCREENING IN A PUBLIC HOSPITAL: A RETROSPECTIVE COHORT

Pinós, Douglas Da Silva
Introduction: Cancer is currently the second cause of mortality worldwide. Among the most prevalent are breast, cervical and colorectal cancer, which population screening is indicated and available by the Unified Health System (SUS). This study evaluates the rate of screening performed for breast, cervical and colorectal cancer, among patients assisted...
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SYNCHRONOUS TESTICULAR SEMINOMA AND NEUROENDOCRINE LUNG TUMOR: AN ATYPICAL PRESENTATION

Ferreira, Kamila Fernandes
Case presentation: A 24-year-old patient with no comorbidies and no relevant past medical history or family history noted a mass in his right testicule in March 2020. Computed tomography (CT) scans showed a lung nodule in the right lower lobe, measuring 1.8 cm and a liver nodules in the segments...
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GENOTYPING OF THE GERMLINE PATHOGENIC VARIANT R337H TP53 AND ITS GENETIC PREDISPOSITION TO SARCOMAS IN THE ABSENCE OF PHENOTYPES ASSOCIATED WITH LI-FRAUMENI SYNDROME

Carmo, Juliana Ramos
Introduction: Although they usually occur sporadically, genetic susceptibility is a risk factor for several types of sarcomas. In particular, the occurrence of familial sarcoma has been the basis of the clinical definition of Li-Fraumeni syndrome (LFS) (involving variations in the TP53 gene) since its first description in 1969, consequently, most...
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Orbital Non-Hodgkin Lymphoma: a single institution analysis on therapy outcomes and therapy induced Second Primary Malignancies

Dias, Rodrigo Souza
Introduction: Primary non-Hodgkin´s Lymphoma (NHL) of the orbit is a rare presentation and radiation therapy (RT) is considered the standard treatment for initial stage disease and low-grade NHL. Radiation therapy side effects include cataracts, dry eye, retinopathy, and others. Another concern when using Radiation therapy is the risk of development...
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SARCOMA PATIENTS CHARACTERISTICS IN AN ONCOLOGICAL REFERENCE CENTER IN SOUTHERN BRAZIL

Moreira, Shermann Brandão Rodrigues
Introduction: Sarcomas are a rare and heterogeneous group of tumors, originated at mesenchymal cells and represent nearly 1% of all adult câncer. Sarcomas are divided in two large groups: soft tissue sarcomas and bone sarcomas. Objective: To know the characteristics of sarcoma patients in a hospital in southern Brazil and...
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THE ANTICANCER AND BIOLOGICAL ROLE OF R-CARVONE AND ALPHA-PHELLANDRENE

Lima, Lucas Trevisan França De
Introduction: Alternatives to the ongoing cancer treatments are extremely important and highlighted nowadays in order to improve patient's quality of life by reducing induced limitations and adverse effects. Accordingly, natural compounds have an important role since they may present anticancer effects associated with less toxicity; in this context, monoterpenes show...
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CLINICAL AND PATHOLOGICAL FEATURES OF AGGRESSIVE VARIANTS OF PAPILLARY THYROID CARCINOMA: A CASE SERIES AT A BRAZILIAN INSTITUTION

Lopes, Moisés De Sousa Martins
Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy with aggressive variants being recognized. Some of these variants can have higher rates of metastasis, recurrence, resistance to radioactive iodine therapy. Objective: Here we report our case series of aggressive variants of PTC, focusing in frequency and clinical and...
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FEASIBILITY STUDY OF A PATIENT-REPORTED OUTCOMES PROGRAM IN A BRAZILIAN CANCER CENTER

Silva, Araceli Vicente Da
Introduction: Patient-reported outcome (PROs) programs can add great value to cancer care. Routine assessment of PROs can enable healthcare teams to improve symptom management and communication with patient and caregivers. Objective: We sought to establish the feasibility of a Brazilian PROs program for patients with cancer starting chemotherapy. Methods: This...
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PHYSICAL EXERCISE AND QUALITY OF LIFE OF PATIENTS DIAGNOSED WITH COLORECTAL CANCER: SYSTEMATIC LITERATURE REVIEW

Silva, Marianne Lucena Da
Introduction: Colorectal cancer is the third most diagnosed neoplasm in men and the second in women. Although treatment improves patient survival, the literature points to numerous adverse effects which culminates in reduced quality of life. In this sense, it is known that the practice of physical exercises brings great benefits...
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BOTH ANTI-EGFR ANTIBODIES ARE SIMILARLY ACTIVE IN COMBINATION WITH IRINOTECAN IN METASTATIC COLORRETAL CANCER (MCRC) THAT HAVE PREVIOUSLY PROGRESSED ON IRINOTECAN

Braghrioli, Maria Ignez
Introduction: The anti-EGFR antibodies have been used either in combination or monotherapy for mCRC. Previous studies have demonstrated that the tumor resistance to irinotecan could be reversed by the addition of cetuximab. However, there is no data regarding the combination with panitumumab. Objective: The present study aims to assess the...
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NEW ANTICANCER DRUGS FOR SOLID TUMORS IN THE LAST 10 YEARS: DIFFERENCES IN APPROVAL AND ACCESS BETWEEN THE UNITED STATES AND BRAZIL IN THE PUBLIC AND PRIVATE SECTORS. Authors: RAFAEL BALSINI BARRETO (CENTRO DE PESQUISAS ONCOLOGICAS – CEPON – FLORIANÓPOLIS – Santa Catarina – Brasil), ANDRESSA MORETTI IZIDORO (CENTRO DE PESQUISAS ONCOLOGICAS – CEPON – FLORIANÓPOLIS – Santa Catarina – Brasil), SAULO BRITO SILVA (FACULDADE DE MEDICINA DE RIBEIRÃO PRETO – UNIVERSIDADE DE SÃO PAULO – RIBEIRÃO PRETO – São Paulo – Brasil)

Silva, Saulo Brito
Introduction: Advances in cancer treatment happen, in part, due to the creation of new anticancer drugs (ACD). In recent years, ACDs with new mechanisms of action were developed through the discovery of new targets or new ways to block them, however access to these drugs is uneven across different countries...
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Perfil Sociodemográf¡co e Clínico de Crianças Submetidas à Radioterapia no Instituto Nacional de Câncer

Magalhaes, Guilherme Araujo
Introduction: INCA is a reference center for cancer treatment in Rio de Janeiro, both for adults and children, and is part of the highly complex network of the Unified Health System (SUS). The treatment of childhood cancer is multidisciplinary, and like chemotherapy and surgery, radiotherapy is part of this approach,...
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MORTALITY FROM PANCREATIC CANCER IN BRAZIL BETWEEN 2009 AND 2019

Silva, Gessica Barbosa Da Silva E
Introduction: In Brazil, pancreatic cancer represents 2% of all types of cancer, being the eighth cause of death regarding other types of cancer. The worst prognosis of the disease has relationship with diagnosis at a locally advanced or metastatic stage of the disease. Still no diagnostic methods can accurately detect...
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CHRONOLOGICAL ANALYSIS OF PATIENTS WITH A DIAGNOSIS OF INVASIVE BLADDER MUSCLE UROTHELIAL CANCER RELATED TO IMPACTS ON CONDUCT AND SURVIVAL

Santos, Rodrigo Dos
Introduction: Muscle invasive bladder neoplasm is among the leading causes of premature death worldwide. With a high potential for lethality, muscle invasive bladder cancer requires aggressive treatment and multimodal management. In the public health context, there are obstacles that can go against the therapeutic objective. Organizations and programs aiming to...
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EVALUATION OF THE EFFICACY OF OVARIAN FUNCTION SUPPRESSION WITH 3-MONTH-LY GONADOTROPIN-RELEASING HORMONE ANALOGUE REGIMEN IN PREMENOPAUSAL BREAST CANCER

Jardim, Debora De Melo Gagliato
Introduction: A previous phase 3 trial demonstrated that 3-monthly goserelin 10.8 mg was non-inferior to monthly goserelin 3.6 mg for progression free survival (PFS) rate at 24 weeks, in premenopausal women with early estrogen receptor (ER)-positive breast cancer, who received concomitant tamoxifen 20 mg daily. However, the efficacy of 3-montlhy...
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Low-grade chondrosarcoma in the metacarpal region in a young patient and complications after surgical excision: a case report

Costa, Alessandra Martinelli
Case presentation: A 22-year-old female patient underwent surgery for the conservative excision of a tumor mass in the distal region of the 5th right metacarpal bone, after confirmation of the diagnosis of low-grade chondrosarcoma. The suspicion was due to the presence of a painful mass in the hand for more...
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Distress and quality of life among treatment-naïve patients before and during COVID-19 pandemic

Molina, Lorena Nascimento Manrique
Introduction: The COVID-19 pandemic has dramatically impacted the way patients with cancer may request and receive psychosocial support. Thus, patient-reported outcomes (PROs) have become even more critical in the identification of patients with high distress. Objective: This study compares differences in psychosocial outcomes (distress and quality of life (QOL)) reported...
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PROGRESSION OF NON-MELANOMA SKIN CANCER CASES IN BRAZIL

Bitzcof, Bruna Tifani
Introduction: Skin cancer is a pathology of multifactorial etiology, resulting mainly from genetic alterations, environmental factors and lifestyle. There are three major types of skin cancer: melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin cancer and they are...
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IMPACT OF THE USE OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) ON THE OUTCOME OF PATIENTS WITH METASTATIC PANCREATIC ADENOCARCINOMA TREATED WITH FOLFIRINOX: A RETROSPECTIVE ANALYSIS

Brito, Angelo Borsarelli Carvalho
Introduction: FOLFIRINOX stands as a major breakthrough in the management of metastatic pancreatic ductal adenocarcinoma (PDAC). However, this protocol is associated with a high frequency of neutropenia. Despite its frequent use in clinical practice, the role of granulocyte colony-stimulating factor (G-CSF) prophylaxis during the treatment with FOLFIRINOX is unclear. Objective:...
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Neoplasia de Esôfago na Infância: Relato de Caso

Magalhaes, Guilherme Araujo
Case presentation: JCPS, 9 years old, female, black, born in Rio de Janeiro. Onset of dysphagia and weight loss, evolving with right cervical adenomegaly. Computed tomography in an Emergency Hospital showed esophageal thickening and after an unsuccessful attempt to pass the nasogastric tube, parenteral nutrition was iniciated. Transferred to a...
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REASSESSMENT OF LOW- AND INTERMEDIATE-RISK ENDOMETRIAL CANCER REPORTS BY GYNECOLOGICAL PATHOLOGISTS INCREASES RISK CLASSIFICATION WITHOUT IMPACTING OUTCOME

Andrade, Diocesio Alves Pinto De
Introduction: Endometrial cancer (EC) is the fourth most common type of cancer, and the most prevalent gynecological tumor among women in the USA. The review of non-specialist pathology reports by specialist pathologists can lead to significant differences in tumor grades, which may affect patients’ prognosis and treatment. Four histopathological variables...
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Navigation in oncology: adding quality and wholeness to care

Vargas, Sheron Tannara
Case presentation: PRESENTATION: The present research describes a case of assisted navigation in nursing care, which evidenced the importance of this program in minimizing clinical barriers and/or complications related to oncological treatment. A woman aged 58 diagnosed with breast cancer was assisted. The treatment plan consisted of six cycles of...
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END-OF-LIFE COST IN A CANCER PATIENTS IN A REFERENCE HOSPITAL IN SOUTHERN BRAZIL

Vargens, Andre Freitas
Introduction: The high end-of-life cost of cancer patients may be associated with a worse quality of death and show an inadequate use of health resources. The assessment of hospital costs at the end of life of cancer patients may be useful for a better understanding of the quality of care...
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PARANEOPLASTIC FEVER ASSOCIATED WITH LOCALIZED SOFT TISSUE SARCOMA: CASE REPORT

Martins, Juliana Goes
Case presentation: A 19-year-old, female, presented amenorrhea, fever and ocasional low back pain. Laboratory tests detected microcytic and hypochromic anemia and elevated ferritin, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). The patient was referred to the hematologist and clinical oncologist who decided to investigate as anemia of chronic disease,...
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DISCORDANCE BETWEEN THE INITIAL DIAGNOSIS OF SARCOMAS AND SUBSEQUENT HISTOPATHOLOGICAL REVISION AND MOLECULAR ANALYSES IN A REFERENCE ONCOLOGY CENTER IN BRAZIL

Queiroz, Marcello Moro
Introduction: Sarcomas correspond to a group of rare and heterogeneous tumors of mesenchymal origin. The accurate diagnosis of sarcomas represents a major challenge due to the diversity of demographic, phenotypic/pathologic, and molecular aspects. These hurdles are further enhanced in developing countries due to the limited availability of specialized pathology centers,...
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THE USE OF RADIOLOGICAL CONTRAST MEDIUM IN RADIOTHERAPY PLANNING -APPLICABILITY FROM THE TECHNICAL POINT OF VIEW

Fernandes, Giordano Masini
Introduction: The contrast medium used in computed tomography (CT) is iodinated contrast, a radiodense substance that allows for the differentiation of different structures. As with CT scans for diagnosis (CTD), in CT for radiotherapy planning (CTRP) the contrast may be indicated by the radiotherapist. Thus, knowledge about the contrast mechanism...
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CLINICAL-EPIDEMIOLOGICAL AND MORTALITY PROFILES BY GASTRIC CANCER IN BRAZIL: COMPARATIVE ANALYSIS BETWEEN STATES

Figueiredo, Emanuel Veríssimo
Introduction: In Brazil, gastric cancer is the third most frequent neoplasm among men and the fifth among women. Adenocarcinoma is about 95% of the cases. Excess weight, alcohol consumption, smoking and pre-existing illnesses are important risk factors. Objective: Draw clinicalepidemiological and mortality profiles of gastric cancer cases in Brazil in...
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TECHNICAL ASPECTS OF COMPUTED TOMOGRAPHY APPLIED IN IMAGING DIAGNOSIS AND RADIATION THERAPY

Fernandes, Marco Antonio Rodrigues
Introduction: Computed tomography (CT) can be used for diagnosis (CTD) and for radiotherapy planning (CTRP), due to the excellent differentiation and resolution of tissues with the acquisition of three-dimensional images. In planning radiotherapy, it is essential to correctly determine and optimize the dose distribution in the planning target volume (PTV)...
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Use of chamomile tea to treat dry desquamation in head and neck cancer patients undergoing radiotherapy

Bontempo, Priscila De Souza Maggi
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Reis, Paula Elaine Diniz Dos
Introduction: Radiation dermatitis is a common skin reaction resulting from exposure to ionizing radiation. It can manifest as erythema, dry desquamation, moist desquamation, ulceration, and necrosis. Chamomile (Chamomilla recutita) has been used as anti-inflammatory, healing, antimicrobial, antioxidant, hemostatic, and skin irritation. Objective: To evaluate the effect of using a chamomile...
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Definitive Intensity modulate radiotherapy for stage IV sinonasal inverted papilloma

Arruda, Gustavo Viani
Case presentation: A 34 years-old female complained of nasal obstruction for two years. Video-nasofibroscopy showed a large lobulated and polypoid tumor, of rough surface and firm, occupying the all the lateral wall of the nasal cavity. Nasal and paranasal sinuses computed tomography CT and magnetic resonance image (MRI) scan revealed...
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Laryngeal paraganglioma: a case report

Cantidio, Farley Soares
Case presentation: Case presentation: Female, 78-year-old, with no tobacco and alcoholic history, complaint of progressive hoarseness, and difficulty in swallowing solid food started clinical investigation. She had diabetes, hypothyroidism, and heart disease as comorbidities. The head and neck surgeon evaluation confirmed a nodule vocal folds lesion by the video laryngoscopy...
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Case report: Synovial sarcoma of the axilla with axillary nerve involvement

Duarte, Mayza Lemes
Case presentation: A 42-year-old woman patient noticed a painless mobile lump in her left axilla about six months prior. Her biopsy revealed synovial sarcoma. The mass did not change in size over this period. It was associated with increased pain and numbness involving her left arm. No adjacent lesions or...
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INTRONIC VARIANTS OF MITF (RS7623610) AND CREB1 (RS10932201) GENES MAY ENHANCE SPLICING EFFICIENCY IN HUMAN MELANOMA CELL LINE

Carron, Juliana
Introduction: Cutaneous melanoma (CM) is the most aggressive form of skin cancer. MITF and CREB1 pathway is crucial in CM development and progression. We previously reported that single nucleotide variations (SNVs) in MITF (c.938-325G>A, rs7623610) and CREB1 (c.303+373G>A, rs10932201) genes were associated with risk, aggressiveness, and worse prognosis of CM....
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PSEUDOGENE TRANSCRIPTS IN HEAD AND NECK CANCER: IN SILICO ANALYSIS

Lourenço, Gustavo Jacob
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Coletta, Rafael Della
Introduction: Once considered nonfunctional, pseudogene transcripts are now known to provide valuable information for cancer susceptibility and progression, including head and neck cancer (HNC), a serious health problem worldwide. Pseudogene transcripts might interact with the promoter of the parent gene or act as a microRNA decoy, controlling gene expression and...
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OUTCOMES IN EARLY STAGE OVARIAN CANCER WITHOUT LYMPHADENECTOMY: A RETROSPECTIVE COHORT STUDY IN A REFERENCE ONCOLOGICAL HOSPITAL

Campos, Felipe Franco De
Introduction: Ovarian carcinoma represents the most aggressive gynecological tumor. Most metastatic dissemination of this tumor occurs through transcelomic route or lymphatic vessels. The incidence of nodal metastases is substantially lower in neoplasms detected in early stages compared to more advanced stages. The efficacy of lymphadenectomy in early stages is not...
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NEGATIVE HHV-8 IMMUNOREACTIVITY IN LYMPHANGIOMA-LIKE KAPOSI’S SARCOMA

Pêgo, Rayssa Leite
Case presentation: Female patient, 66 years old, presenting asymptomatic erythematous-violaceous macules on the medial surface of the right and left feet, for about 20 years. Biopsy was performed and the histopathologic analysis revealed alterations compatible with lymphangioma and positive immunohistochemistry for CD31, CD34 and negative for human herpesvirus 8 (HHV-8)....
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SUBCUTANEOUS DARATUMUMAB: EXPERIENCE REPORT IN AN ONCOLOGY CLINIC IN RIO DE JANEIRO

Machado, Larissa Dos Santos Talarico
Introduction: Daratumumab is a monoclonal antibody directed to CD38 and is indicated for the treatment of newly diagnosed, relapsed and/or refractory Multiple Myeloma through intravenous infusion. Although it is a drug with proven efficacy, it has a high risk of reaction related to the infusion and therefore its administration must...
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STRATEGIES ADOPTED IN COPING WITH COVID-19 AIMED AT THE MENTAL HEALTH OF ONCOLOGY PROFESSIONALS: AN EXPERIENCE REPORT

Almeida, Juliana Allevato Moreira Diepes De
Introduction: Brazil and the world have been facing great challenges imposed by the COVID-19 pandemic. So we are in a process of constant change and re-adaptation, in order to always offer the lowest risk for patients and professionals. Objective: To report the experience of coping with covid-19 mental health for...
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DEVELOPMENT OF A NUTRITIONAL SCREENING PROGRAM TO IDENTIFY CANCER PATIENTS AT RISK OF MALNUTRITION AND EXPEDITE TREATMENT AND CAREFUL FOLLOW-UP

Nascimento, Karla Lucia
Introduction: Malnutrition is a major health complication among patients with cancer. It is well-known that cancer-associated malnutrition can impact an individual's treatment tolerance, length of hospital stays, rates of clinical and surgical complications, morbidity, and mortality. Objective: This study sought to determine the impact of an initial nutrition assessment and...
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QUALITY OF LIFE OF PATIENTS WITH LOCALLY ADVANCED UTERINE CERVICAL CANCER SUBMITTED TO CURATIVE TREATMENT

Gama, Layse Martins
Introduction: Women with cervical cancer commonly experience daily physical, psychological and social suffering that cannot be easily attributed to the disease. There is a lack of information regarding this subject in low-middle income countries. Objective: To evaluate the effect of radiotherapy on the quality of life (QoL) of patients with...
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ACTIONS IMPLEMENTED IN ONCOLOGY TO FACE THE COVID-19 PANDEMIC

Diorio, Cibele Aparecida
Case presentation: The beginning of the COVID-19 pandemic aroused great concern among health professionals, especially in oncology, because little is known about the disease and its impact on immunocompromised patients. Therefore, numerous discussions were held to implement measures to combat COVID-19. Objective:To present actions developed to prevent the spread of...
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case report: cancer of the urachus

Simosono, Maysa Lemos
Case presentation: 63 years old, male, with a bladder mass on ultrasound in May/2019. He underwent cystoscopy with biopsy, Anatomopathological (AP): Moderately Differentiated Invasive Mucinous Adenocarcinoma of probable etiology of the urachus. In June/2019, he performed Partial Cystectomy with en bloc resection of the urachus, part of the left colon...
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PLATINUM-BASED CHEMOTHERAPY FOR HORMONE RECEPTOR-POSITIVE HER2-NEG-ATIVE METASTATIC BREAST CANCER: 10-YEAR DATA FROM A BRAZILIAN CANCER CENTER

Uratani, Lucas Fernando
Introduction: Platinum-based chemotherapy (CT) regimens are active in triple-negative breast cancer, with overall response rates around 50%. Evidence of activity is scarce for hormone receptor (HR)-positive breast cancer. Objective: We evaluated the effectiveness of platinum-based CT for HR-positive HER2-negative metastatic breast cancer (mBC). Methods: HR-positive HER2-negative mBC patients who have...
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REMOTE DIGITAL MANAGEMENT OF METASTATIC RENAL CANCER PATIENTS USING SUNITINIB

Pereira, Igor Alcântra
Introduction: Renal cell carcinomas (RCC) are the seventh most common histological type of cancer in the world. Those with inoperable or metastatic RCC often undergo treatment with targeted agents and/or checkpoint inhibitors. It is common that patients using tyrosine kinase inhibitors present severe adverse (TKI) symptoms that impact their quality...
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IDENTIFICATION OF VARIANTS (RS11571707, RS144848, AND RS11571769) IN THE BRCA2 GENE ASSOCIATED WITH HEREDITARY BREAST CANCER IN INDIGENOUS POPULATIONS OF THE BRAZILIAN AMAZON

Medeiros, Jéssyca Amanda Gomes
Introduction: Estimates show that 5% -10% of breast cancer cases are hereditary, caused by genetic variants in autosomal dominant genes; of these, 16% are due to germline mutations in the BRCA1 and BRCA2 genes. The comprehension of the mutation profile of these genes in the Brazilian population, particularly in Amazonian...
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CLINICAL PROFILE OF PATIENTS AT RISK OF HEREDITARY BREAST CANCER IN THE PUBLIC HEALTH SYSTEM OF THE FEDERAL DISTRICT, BRAZIL

Weis, Luiza Nardin
Introduction: Identifying patients (pts) with breast cancer (BC) harboring germline pathogenic variants (GPVs) is important due to clinical implications about genetic counseling and cancer surveillance for the patients and its relatives. Even though the cost-effectiveness of genetic testing for the detection of GPVs has already been proven, this technology is...
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Case report: Adenoid cystic carcinoma of the lacrimal gland with intracranial invasion and single lung metastasis

Soares, Ricardo De Alarcão
Case presentation: A 52-year-old woman had right eye ptosis about 2 years prior evolving with worsening of symptoms during the last months associated a lacrimal mass presented with exophthalmos, local pain and visual disturbance in the right eye. Orbital MRI showed a well-circumscribed mass at lateral aspect of the right...
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Curative treatment for stage IIIC2 cervical cancer: what to expect?

Vonsowski, Matheus Sorgi
Introduction: Radical treatment of patients with uterine cervix cancer and positive para-aortic lymph nodes is a valid approach. In this regard, the Federatión Internationale de Gynecologie et Obstetrice (FIGO) staging has changed in 2018. Objective: To evaluate overall survival (OS), pelvic disease-free survival (PDFS), paraortic lymph node progression (PANP) and...
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ACTIVE FOLLOW-UP OF PANCREATIC ADENOCARCINOMA: THE IMPACT ON DIAGNOSING RELAPSE AND OVERALL SURVIVAL

Jesus, Victor Hugo Fonseca De
Introduction: Pancreatic cancer has a poor prognosis, even in patients with localized disease undergoing curative treatment. It is estimated that only 20% of these patients will be alive in 5 years. Most of them will relapse within the first 2 years, with a median overall survival of 3-7 months. Although...
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Sars-Cov2/COVID-19 impact on breast cancer radiotherapy practice: A single institution analysis

Peixoto, Caio Lima
Introduction: Sars-Cov2/COVID-19 pandemic is an international healthy emergency issue. Several Radiotherapy centers developed hypofractionation (HF) protocols to reduce patients visits. In breast cancer (BC), moderate HF (MHF) schemes that were recommended for whole breast irradiation (WBI) after breast conserving surgery before the pandemic, started to be applied in patients undergoing...
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PLATELETS BEHAVIOR IN PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) INFECTED WITH CHRONIC HEPATITIS C (HCV) CONSIDERING GENDER AND AGE

Vasconcelos, Luydson
Introduction: DAYSE AROUCHA (FACULDADE DE CIÊNCIAS MÉDICAS DA UNIVERSIDADE DE PERNAMBUCO/HOSPITAL UNIVERSITÁRIO OSWALDO CRUZ - FCM/HUOC/UPE - RECIFE - Pernambuco - Brasil), ERIKA SIQUEIRA (FACULDADE DE CIÊNCIAS MÉDICAS DA UNIVERSIDADE DE PERNAMBUCO/HOSPITAL UNIVERSITÁRIO OSWALDO CRUZ - FCM/HUOC/UPE - RECIFE - Pernambuco - Brasil), JOÃO VICTOR FARIAS (INSTITUTO DE CIÊNCIAS BIOLÓGICAS...
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RETROSPECTIVELY NEPHROTOXICITY EVALUATION ON THE HEAD AND NECK CANCER PATIENTS TREATED WITH HIGH-DOSE CIS-PLATIN CHEMOTHERAPY

Furtado, Anne Caroline Teixeira Cavalcanti
Introduction: Head and neck cancer (HNC) is diagnosed at a locally advanced stage in 60% of cases. When surgery is not feasible, a combination of high-dose cisplatin (CDDP) chemotherapy and radiotherapy is the standard care. However, the overall prevalence of nephrotoxicity approaches one-third of cases and it can negatively impact...
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Caring for Colorectal Cancer Patients: the Perspective of Informal Caregivers in Brazil

Neumann, Lycia Tramujas Vasconcellos
Introduction: In Brazil, it is estimated that 55,102 individuals were newly diagnosed with colorectal cancer in 2020. It is the third most common cancer among men and women, with an estimated 25.9 new cases per 100,000 people. Little is known about the impact of caring for a cancer patient on...
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GIANT CELL TUMORS OF BONE: A BRAZILIAN EPIDEMIOLOGICAL PROFILE EVALUATION

Cesca, Marcelle Goldner
Introduction: Giant cell tumor of bone (GCTB) is a rare locally aggressive osteolytic skeletal neoplasm of young adults. It is generally characterized by a unique lesion in the metaepiphyses of the long bones and infrequently metastasize to the lungs. Objective: To evaluate the epidemiological and clinical profile of patients (pts)...
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NEUROENDOCRINE MARKERS AS A PROGNOSTIC TOOL IN SMALL CELL LUNG CARCINOMA UNDERGOING CHEMOTHERAPY

Wanderley, Carlos Wagner Souza
Introduction: Small cell lung carcinoma (SCLC) has recently been classified into four molecular subtypes, according to differential key transcription regulators expression. Among these, ASCL1 and NEUROD1 double negative subtypes, in addition to POU2F3 or YAP1 positive subtypes, are characterized by having either low or absent neuroendocrine (NE) markers on immunohistochemical...
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NON-OPERATIVE MANAGEMENT WITH A WATCH AND WAIT PROTOCOL IN RECTAL CANCER: A SINGLE-CENTER RETROSPECTIVE ANALYSIS OF CLINICAL OUTCOMES AND THE IMPACT OF MAGNETIC RESONANCE IMAGING

Silva, Saulo Brito
Introduction: The non-operative rectal cancer approach, through watch and wait (WW) protocol, has increasingly been accepted as an option for patients who achieve a complete or near-complete clinical response after neoadjuvant therapy. Nonetheless, the recurrence rates reported in several retrospective trials and, recently, prospective trials have varied substantially. Objective: We...
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CLINICAL IMPACT OF DE-ESCALATING CHEMOTHERAPY IN METASTATIC COLORECTAL CANCER: A REAL-WORLD ANALYSIS OF A TERTIARY CANCER CENTER

Silva, Saulo Brito
Introduction: Several clinical trials have evaluated the role of de-escalating systemic treatment in metastatic colorectal cancer (mCRC) through maintenance (M) or chemotherapy-free interval (CFI). Yet, evaluation of these strategies in a real-life setting, aside from controlled trials, remains underexplored and may contribute to clinical practice. Objective: We sought to evaluate...
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QUALITY AND VALUE-BASED HEALTHCARE (VBHC) FOR PATIENTS WITH NON-META-STATIC COLON CANCER AT A BRAZILIAN REFERRAL HOSPITAL

Nasi, Luiz
Introduction: Focused on best practices, our institution has value-based healthcare (VBHC) and International Consortium for Health Outcomes Measurement (ICHOM). We reported clinical data of patients with colon cancer, mapping pathological characteristics and treatments in order to improve the quality of the medical care provided. Objective: Evaluate methods of diagnosis, treatment...
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CLINICAL IMPACT OF MONOCLONAL ANTIBODY USE IN METASTATIC COLORECTAL CANCER PATIENTS TREATED IN A BRAZILIAN PUBLIC HOSPITAL CANCER CENTER

Silva, Saulo Brito
Introduction: Monoclonal antibodies (MABs) targeting tumor angiogenic and epithelial growth factor receptor pathways have improved survival in metastatic colorectal cancer (mCRC). While strategies evaluating individualization of MABs to optimize survival in mCRC remain a motive of clinical investigation, patients (pts) submitted to institutional protocols, such as those in public hospital...
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A REAL-WORLD EFFECTIVENESS OF PERIOPERATIVE FLOT REGIMEN IN GASTRIC CANCER

Barreto, Rafael Balsini
Introduction: Perioperative chemotherapy (chemo) with the FLOT regimen has become one of the most common strategies utilized in non-metastatic gastric cancer (GC). However, there are no prospective comparisons with upfront surgery followed by adjuvant chemo, which could prompt questions regarding consideration as the standard of care. Objective: We aim to...
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OXALIPLATIN-INDUCED-IMMUNE OR IDIOPATHIC THROMBOCYTOPENIC PURPURA: CASE REPORT

Faria, Aline De Oliveira
Case presentation: Patient M.I.S.S., female, 52 years old, hypertensive using atenolol 25mg/day and social drinker, diagnosed with colon adenocarcinoma (rectosigmoid), performed left hemicolectomy and lymphadenectomy on November 2017, pathological stage IIIC, followed by adjuvant chemotherapy on the FOLFOX scheme (5-FU, leucovorin and oxaliplatin) for 6 months. She began follow-up until...
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ANALYSIS OF THE EFFECTIVENESS AND TOXICITIES OF WEEKLY ADJUVANT CHEMOTHERAPY IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

Avelar, Camila Reis Teixeira
Introduction: Head and neck cancer (HNC) have a high incidence in Brazil, representing more than 8% of tumors in males. Patients presenting respectable lesions (stage III and IV) are treated with surgery followed by adjuvant chemo-radiotherapy with high-dose cisplatin (CDDP). This regiment has been considered standard of care for several...
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THE USE OF THE “LEAN” METHODOLOGY FOR IMPROVEMENTS AND SAFETY IN PATIENTS’ PROCESSES IN AN ONCOLOGY OUTPATIENT CLINIC

Navas, Cristiane Oliveira Azzalin
Introduction: The term “”Lean“” in the area of health is defined as the maximization of value for the client through an efficient and waste-free process. This approach seeks to provide services that respect the needs of patients, prioritizing and ensuring the safety of the process 1 2. In addition, it...
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