Prezados Colegas, A abordagem multidisciplinar do câncer tem sido considerada um dos maiores avanços no tratamento oncológico e seus benefícios aos pacientes estão fartamente documentados na literatura científica. Além disso, acompanhar a grande quantidade e velocidade de informação criada atualmente na área de Oncologia, torna-se uma tarefa cada vez mais...
Background: Triple-negative breast cancer (TNBC) accounts for about 15% to 20% of breast cancer diagnoses and has an aggressive natural history and poor prognosis. Patients who do not get a pathologic complete response (pCR) after neoadjuvant chemotherapy have a higher risk of relapse. Objectives: To evaluate the pCR in patients...
Introduction: Penile cancer is an aggressive and rare disease, with incidence less than 1% of male malignancies in the US and Europe. However, the incidence reaches 10% in developing countries such as Africa and South America. In Brazil, penile cancer stands for 2% of the tumor types, one of the...
Introduction: Most antineoplastic agents offer risks regarding the occurrence of adverse reactions to infusion. The incidence and profile of these reactions vary according to the pharmacological characteristics of each medicine, and may or may not be immunomediated. Due to their systemic unspecific action, chemotherapeutics act indiscriminately throughout the body, which...
Introduction: Oncological patients are mostly treated in ambulatorial scenarios but may demand complex in-hospital care. At our university-teaching hospital, we conduct 15.000 ambulatory consults yearly. Objectives: Analyze data regarding patients in need of hospital care admitted in our Oncology infirmary aiming better clinical practices, clinical support and scope for financial...
Rationale: Locally Advanced Triple-Negative Breast Cancers (LATNBCs) are tumors with a high rate of relapse and death, and there is a strong need to explore reliable social and pathological biomarkers. Based on molecular profile, TNBC have been classified into five subtypes with different immunohistochemical profile. Methods: This is a single-institutional,...
EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH ESOPHAGEAL CANCER TREATED AT THE ONCOLOGY OUTPATIENT CLINIC IN THE PUBLIC HEALTH SYSTEM OF THE SÃO LUCAS HOSPITAL OF THE PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL (HSL-PUCRS)
Introduction: Esophageal cancer is the fifth cause of death due to malignant neoplasm in men in Brazil. Late diagnosis is a poor prognostic factor and the difficulty of access to specialist consultation contributes to the therapeutic delay, worsening of the patient's clinical condition and can result in a lower overall...
Increase incidence of cancer and improvement of treatment led to a better management of these patients in Intensive Care Units (ICU). However, it is known that ICU admission is associated with worse prognosis, depending on the stage of disease, the acute intercurrence and organ failure number. In parallel, it is...
Introduction: In a controversial context about prostate cancer screening in general population - the Brazilian Health Department does not indicate and others International societies sent your guidelines - the Brazilian Urology Society, through an official note from 2017, recommends starting at 50 years looking for the specialist annually for assessment...
EVALUATION OF THE HEALTH PROMOTION OF WOMEN WITH BREAST CANCER IN PRIMARY HEALTH CARE IN A MUNICIPALITY IN THE SOUTH OF MINAS GERAIS: AN OBSERVATIONAL STUDY
Introduction: In Brazil, excluding non-melanoma skin tumors, breast cancer (BC) is the most frequent among women, being also a leading cause of death in this population. In order to reduce the morbidity and mortality caused by BC, the Primary Health Care (PHC), which is the structuring axis of the Unified...
Introduction: The role of adjuvant chemotherapy (ACT) after curative resection of colorectal cancer (CRC) is eradication of micrometastatic disease, decreasing the recurrence and improving the overall survival, but for patients with stage II CRC is an area of controversy in oncology. Current guidelines recommend ACT forpatients with high-riskfactors. However, chemotherapy...
Introduction: Cancer patients require great care and attention, because usually the disease and the treatments deteriorate their quality of life. In this perspective, palliative care is highlighted as an approach to care for patients and family caregivers. Objective: To identify in the national scientific literature what are the caregivers experiences...
Background: In castration-resistant prostate cancer (CRPC), the skeleton is the most common metastatic site, decreasing patients quality of life and survival. Radium-223 is an alpha particles emitter which are selectively accumulated in the bone, producing a palliative anti-tumor effect on these metastases, improving overall survival and the time to first...
Introduction: Esophageal cancer is one of the most frequent and lethal malignant neoplasms in the world, being the third cause of death by digestive cancer. The histological type of the disease is related to its etiology, being squamous cell carcinoma responsible for 96% of the cases and related to smoking...
Introduction: In 40 years, several studies on the development of ophthalmological pathologies, including glaucomas, have been carried out in patients with leukemia. Statistics show that even underdiagnosed and varying from 2 - 3% among older studies, the frequency of open and closed angle glaucoma in leukemic patients in both children...
Introduction: Gastric cancer is one of the leading causes of cancer death in the world due to its prevalence and bad prognosis. DNA repair system genes are candidates for cancer susceptibility. XRCC (X-ray repair cross-complementing) genes are family members of the DNA repair system, which are polymorphic with several non-synonymous...
Introduction: Bladder cancer is the most common neoplasm of the urinary tract and the 9th most incident in the world, being more diagnosed between the 6th and 7th decades of life. With heterogeneous characteristics, 70% of the patients presented superficial tumors, and 30% an invasive muscular disease associated with high...
Introduction: Gastric tumors have an initially silent clinical picture or nonspecific manifestations, repercuting on a late diagnosis, the main reason for the poor prognosis of this condition. Among the gastric expansive lesions, the adenocarcinoma corresponds to 90% of the cancers that involve the organ, with peak in incidence at 60...
Introduction: Lung cancer is the leading cause of cancer-related death in the U.S. and worldwide, with nonsmall cell lung cancer (NSCLC) accounting for over 80% of those cases. Programmed death-ligand 1 (PD-L1) expression on tumor cells (TCs) by immunohistochemistry is rapidly gaining importance as a diagnostic for the selection or...
Introduction: The histological classification of Central Nervous System (CNS) tumors has, since 1926, guided clinical decisions in adjuvant treatments. In 2016, molecular testing was integrated to the new WHO classification better correlating to prognosis and clinical outcomes than the prior classification. Clinical trials have established standard adjuvant treatment options over...
Introduction: Data from GLOBOCAN estimate more than 6 million of cancer patients older ≥ to 70 years. As the elderly population is poorly represented in clinical studies, it becomes important to know how these patients are treated. Objective: To evaluate the treatment of patients ≥ 70 years with Gastrointestinal Cancer...
Introduction: High-grade gastroenteropancreatic neuroendocrine neoplasms(GEPNENs) are defined as neoplasms having a high proliferative index with a Ki-67> 20%. They are a highly heterogeneous group, containing tumors that are both well and poorly differentiated. Data on GEP-NENs are limited. We retrospectively studied clinical data GEP-NENs patients. Objective: To characterize patients attended...
Introduction: The aging population is a phenomenon that takes place worldwide, nonetheless some countries that had never a huge elderly population will face out a major change in its population aging distribution, likewise what Brazil is facing nowadays. In this context, it will be more frequent that elderly people will...
Background: The best strategy for maintaining quality of life is the combination of supportive care with chemotherapy in all stages of treatment. In this study we used a specific scale for palliative care seeking to describe longitudinal symptoms of patients in neoadjuvant, adjuvant and palliative chemotherapy. Methods: Observational study conducted...
CHALLENGES IN THE EDMONTON SYMPTOM ASSESMENT SCALE (ESAS) IMPLEMENTATION IN THE ONCOLOGY AND HEMATOLOGY UNIT BY THE INTEGRATIVE MEDICINE GROUP OF A PRIVATE TERCIARY HOSPITAL IN SÃO PAULO: EXPERIENCE REPORT
Case presentation: The use of complementary and integrative medicine (CIM) by cancer patients is well-known in the oncology setting, mostly related to the desire to increase the chances of cure, minimize side effects and also participate actively of their salutogenesis. The Edmonton Symptom Assesment Scale (ESAS) has been used as...
Background: Non-Small Cell Lung Cancer (NSCLC) NSCLC patients may be benefited by tailored treatment based on genomic profiling. However, the genomic landscape of Brazilian NSCLC remains unknown. Aim: to evaluate the genomic profiling of Brazilian NSCLC. Methods: We analyzed 96 NSCLC patients from Barretos Cancer Hospital, Brazil. Exome sequencing from...
Anabolic, infiltrative and diffuse nature of glioblastoma (GBM) impairs complete surgical resection favouring tumor recurrence due to radio and chemoresistance and oncogenic metabolic reprogramming. Despite recent advances on brain imaging, up to now there is no diagnostic tool capable to detect incipient tumor niches and differentiate from inflammatory infiltrate/ radionecrosis....
IMPROVEMENT IN OVERALL SURVIVAL AND QUALITY OF LIFE IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA EXPOSED TO LOW ENERGY AMPLITUDE MODULATED ELECTROMAGNETIC FIELDS
Background: Exposure to amplitude-modulated radiofrequency electromagnetic fields (AM RF EMF) may provide beneficial palliative treatment for patients with advanced HCC (HCC). Methods: A single-group, open-label, prospective study was performed to assess the safety, the impact on quality of life (QoL), and the overall survival (OS) associated with exposure to AM...
Introduction: Solitary fibrous tumor (SFT) is a rare soft tissue sarcoma, with fibroblastic differentiation. It is generally associated with low rates of local recurrence or metastasis (REC/MT). Tumor size, high mitotic rates, necrosis/hemorrhage, positive resection margins and nuclear pleomorphism are suggest to impact prognostic. However, eminent risk factors for aggressive...
EARLY BREAST CANCER RH + / HER2-: MAGEE SCORE AND TENNESSEE NOMO-GRAM AS SURROGATES OF GENOMIC TOOL ONCOTYPE DX: EXPERIENCE IN A BRAZILIAN CANCER CENTER
Introduction: Appropriate selection of adjuvant systemic therapy in early breast cancer RH + / HER2- is classically based on clinical and anatomopathological factors, and recently genomic tests such as Oncotype Dxâ (ODXâ) and Mammaprintâ had refined these decision, mainly avoiding chemotherapy overtreatment. Regarding to ODXâ, some tools were developed in...
Introduction: Grade 3 (G3) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare, with a dismal prognosis. The 2017 WHO subclassified the G3 pancreatic group into high grade (poorly differentiated carcinoma NEC) or neuroendocrine tumors (G3-NET). Yet few data exist on how this subclassification applies to other digestive G3-NEN. Aim: We planned...
Introduction: Chemotherapy with docetaxel (Doc) or hormonotherapy (HT) with abiraterone/enzalutamide (Abi/EZ) are currently options of first-line therapy (1stL) in metastatic castration resistant prostate cancer (mCRPC). However, there are no prospective comparisons that define the best treatment choice in the different presentations of mCRPC. Objectives: The primary objective was to compare...
Introduction: Platinum agents are a paramount class of drug in SCC treatment. Cisplatin and carboplatin became the preferred choices in different squamous-cell tumors, such as head and neck and cervical tumors. Yet, Oxaliplatin is highly active in many gastrointestinal malignancies, like esophageal and gastric adenocarcinoma. We aimed to evaluate the...
Introduction: Although cervical cancer is a potentially avoidable and curable neoplasm, it presents a high incidence and mortality, especially in developing countries where it represents the third most frequent type of cancer and the third cause of cancer death among women. Objective: The objective of this study is to estimate...
Background: Tumor budding (TB) refers to dedifferentiation and loss of tumor cohesiveness and is defined as the presence of cells isolated or agglomerated with at least 5 cells at the tumor front in microscopic analysis. The International Tumor Budding Consensus Conference (ITBCC) in 2016 proposed a scoring system to standardize...
Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. Numerous oncogenic driver alterations associated with non-small cell lung cancer (NSCLC) have been described lately. A breadth of targeted therapies has changed the treatment paradigm for NSCLC. Despite these advances, NSCLC remains a lethal disease, with central nervous system...
Introduction: Microbial diversity has been pointed as a major factor in the development and progression of colorectal cancer (CRC). Objective and Methods: We sought to explore the richness and abundance of the microbial community of a series of colorectal tumor samples treated at Barretos Cancer Hospital, Brazil, through 16S rRNA...
Background: Oncotype DX Recurrence Score (ODXRS) is a 21-gene assay that has been validated for the prediction of recurrence and chemotherapy (CH) benefit in hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) and lymph node negative (pN0) breast cancer. It has also been increasingly used in...
The diagnosis and treatment of cancer can represent changes and impacts, resulting in different emotional reactions. Approximately 10% of the cancers may be hereditary, and through genetic testing it is possible to identify carriers of mutations which increase the risk of developing neoplasia. The knowledge about genetic mutation into a...
Background: With the aging of the population, cancer in the elderly is becoming an increasingly common and complex health problem, particularly in low-middle-income countries. In these settings, the comprehensive geriatric evaluation (CGA), although recommended, is still challenging. Certain components of CGA associated with the risk of early hospitalization in older...
Background: systemic treatment for patients with metastic lung cancer is considered a major advancement in the field of oncology. Although undeniable progress has been made in the treatment of such patients, affordability of the more recently implemented treatments, for people in the less developed parts of the world has been...
Introduction: Molecular profiling of advanced non-small cell lung cancers (NSCLC) is essential in the selection of the candidate population to targeted therapy (TT). TT has greater efficacy, with better response rates, survival and tolerance in comparison to standard therapies such as chemotherapy. Objectives: To determine the mutational profile in NSCLC...
Background: Patients (pts) with neuroendocrine tumors (NET) and carcinoid syndrome may present carcinoid heart disease (CHD) as a late complication of tumor-related hormonal secretion. A multicenter study conducted by our group identified a frequency of CHD of 34.5% among Latin American pts and it was associated with increased mortality. However,...
Introduction: So far, only few studies have investigated the patterns of angiogenesis markers in human Glioblastoma (GBM), mostly focused on vascular endothelial growth factor type A (VEGF-A). Until recently, VEGF-C and -D were not researched targets due to their established primarily role in lymphangiogenesis, which were considered absent in CNS....
PROGNOSTIC IMPACT AND POTENTIAL PREDICTIVE ROLE OF CIRCULATING TUMOR CELLS (CTCS) AND MICROEMBOLI (CTM) IN LOCALLY ADVANCED HEAD AND NECK SQUAMOUS CELL CARCINOMA (LAHNSCC)
Introduction: The prognostic role of CTCs and CTM in locally advanced head and neck squamous cell carcinoma (LAHNSCC) is yet to be determined, with most available trials utilizing cytokeratin dependent techniques for identification and counting of CTCs. The role of induction chemotherapy (ICT) in the management of LAHNSCC is controversial,...
Introduction: Approximately 10% of cancers can be attributed to a germline mutation, confirming an inherited cancer syndrome. Hereditary Cancer Syndrome (HCS) has significant implications in early screening and prevention for the proband and at-risk family members and also is critical for modern oncologic care. Multigene panels have been increasingly used...
Ovarian cancer (OC) comprises heterogeneous and complex diseases group and represents the most lethal gynecologic cancer. In 2018, it was estimated to be responsible for 295,414 new cases and 184,799 deaths worldwide. Late-stage diagnosis associated with a lack of effective molecular markers to detect chemotherapy resistance contributes to high mortality...
Introduction: Colorectal cancer has natural course well described in the literature and has effective therapy when instituted early. On the other hand, its still high mortality rate is due to the late demand for medical care in advanced stages of the disease, with 10% to 15% presenting metastases. The overall...
Introduction: Giant-cell tumor (GCT) is a rare neoplasia, benign but locally aggressive, that causes significant bone destruction. It represents 4 to 10% of primary tumors of bone and occurs mainly in young adults. Definitive treatment is surgical, with complete tumoral resection followed by autograft, homograft, arthrodesis, unconventional endoprostheses or methylmethacrylate....
Patients on Oncologic Palliative Care (OPC), due to diverse symptomatology and variable severity, tend to present polypharmacy that, although it seems justifiable in many cases, can pose health risks and negative consequences on patients' quality of life. Thus, it is necessary to evaluate the presence of possible therapeutic futilities, guiding...
Introduction: Recent studies have shown that a high body mass index (BMI) ( > 24 kg / m2) influences the prognosis of breast cancer patients and the choice of medication in patients with BMI > 30 kg/m2. Objective: To determine the prevalence of obese patients with breast cancer based on...
PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE ANAL (SCCA) AND HIVINFECTION TREATED WITH DEFINITIVE CHEMORADIOTHERAPY (CHRT): A MULTINATIONAL RETROSPECTIVE COMPARATIVE STUDY
Introduction: The definitive treatment for localized SCCA is ChRT in combination with infusional 5-FU. A meta-analysis of published studies from the past decades conducted by our group showed significantly higher dermatological and hematological toxicity and rates of disease-free survival and overall survival at three years significantly lower in HIV-positive patients...
Background: Brain metastases (BM) from colorectal cancer(CRC) are unusual in comparison with other primary sites such as breast and lung. However, an increasing incidence has been reported. The evidence available on the subject is scarce and a better understanding of the disease behavior is warranted. We aimed to characterize the...
Introduction: Studies show that obese patients tend to be submitted to empiric chemotherapy dose reduction, aiming to attenuate adverse effects of the treatment. However, findings suggest that this practice is possibly related to worse clinical outcomes and there is no evidenceof severe toxicity with fulldose administration in this population. Objective:...
Background Adult patients (pts) with localized osteosarcoma have poorer outcomes than pediatric patients in general. One factor that contributes to these poorer outcomes is the elevated toxicity rates with chemotherapy (CT) regimens containing high dose methotrexate in adult pts. Thus, a standard regimen frequently used as neoadjuvant/ adjuvant therapy for...
Background Studying osteosarcoma in adult patients (pts) is challenging due to its rarity. For pts with unresectable or metastatic disease, treatment strategies remain limited, especially after progression on first-line chemotherapy (CT). We studied a cohort of adult pts with osteosarcoma with the aim of evaluating the outcomes and prognostic factors...
Background:The JAK/STAT signaling pathway supports the development, progression and metastatic potential of cutaneous melanoma (CM). The JAK1, JAK2, STAT3 proteins are coded by polymorphic gene in humans, and thus it is possible that normal individuals show inherited differences in pathway functionality. The aim of the study was to evaluate whether...
Melanoma is the 5th most common cancer in men and the 7th in women with 9,320 deaths in 2018 in the U.S. Melanoma molecular basis are well explored and it can guide the patients prognosis and therapy. In Brazil, knowledge of melanoma mutation landscape is limited. Here, we investigated the...
Background: Metastatic biliary tract carcinoma (mBTC) patients are treated in first-line with gemcitabine plus plantinum combination therapy, but survival is poor. Recently, FOLFOX has been shown to be active in second line as compared to active symptom control. However, resistance to a platinum component may impair secondline outcomes and impact...
Introduction: The importance of palliative care covers both the psychosocial aspects and the adequate control of symptoms of those with advanced disease. In the final phase of life, many patients require institutional support. The support beds / long-stay units in services of low complexity can promote the necessary care and...
CORRELATION OF ACTUAL OVERALL SURVIVAL AND SURVIVAL DETERMINED BY ONLINE PROGNOSTIC TOOLS FOR PATIENTS WITH BREAST CANCER: WHAT IS THEIR APPLICABILITY IN CLINICAL PRACTICE?
Introduction: Breast cancer is a public health problem, given its prevalence and the high costs of treatment. In patients with luminal tumors, the selection of the most effective treatment with fewer side effects is sometimes troublesome, and the evaluation is based on genomic tests which are not largely available due...
Introduction: Eccrine porocarcinoma (EP) is rare, accounting for up to 0.01% of all cutaneous tumors. However, it is the most frequent malignant tumor in the eccrine gland, originating from the terminal cells of the intraepithelial portion of the eccrine duct, acrosyringium. In 18 to 50% of cases, it arises from...
Introduction: Locally advanced head and neck squamous cell carcinoma (HNSCC) patients have been treated with cisplatin (CDDP) associated with radiotherapy (RT). The sensitivity and toxicity to CDDP and RT have been associated with single nucleotide polymorphisms (SNPs) in genes that operate in distinct metabolic pathways. Objective: This prospective study aimed...
Introduction: Hand-foot Syndrome (HFS) is common and frequently occurs in the first cycle of treatment in approximately 40 to 50% of patients who receive capecitabine. Turmeric (Curcuma longa) is a plant used by Ayurvedic medicine with clinical activity in various inflammatory conditions. Our objective was to evaluate if turmeric was...
Background:Colorectal cancer (CRC) is the third most malignant neoplasm and the fourth leading cause of cancer death in Brazil. Changes caused by cancer lead to modification in protein-energy metabolism, exacerbated pro-inflammatory state, immune depression and, moreover, affect the ability to ingest or absorb nutrients properly. Despite the substantial improvement in...
Introduction: The incidence of lung cancer in non-and light-smokers is increasing worldwide. There are scarce data about their epidemiology, risk factors and molecular landscape in this population of non small cell lung cancer in Brazil. Objective: Here we aimed to present the first results of a Brazilian prospective and uninstitutional...
Background:The number of Non-alcoholic steatohepatitis (NASH) cases has been increasing in Western countries as Hepatocellular carcinomas (HCC) etiology. However, patients with NASH cirrhosis seems to undertake less intensive screening for HCC than the rest of other cirrhosis etiologies. Although discovering more advanced tumors at diagnosis is intuitively expected, retrospective studies...
Introduction: Breast cancer (BC) is the most frequent among women excluding non-melanoma skin cancer. Its 5-year overall survival (OS) has increased in the last 20 years. One of the reasons is that new therapies have emerged since then. Also, the diagnosis is being made at earlier stages. However, we dont...
Introduction: Breast cancer (BC) treatment vary considerably over different parts of the world. There is a correlation between level of income and efficacy of its management. Therefore, countries of a lower level of income must try to maximize its cost-effectiveness strategies. The ratio of mortality/incidence (RMI) is an indicator of...
Introduction: Acute Lymphoblastic Leukemia (ALL) is the most prevalent malignant neoplasm in children; but, when it happens in adults, ALL becomes a devastating disease. Although, chemotherapy produces positive results in patients first contact with the disease, the possibility of cure is practically null when ALL becomes relapsed/refractory. Objective: To systematically...
SEXUAL AND GENERAL QUALITY OF LIFE ASSESSMENT IN PATIENTS UNDERGOING HORMONAL THERAPY FOR BREAST CANCER: DATA FROM A BRAZILIAN PUBLIC ONCOLOGY DEPARTMENT
Introduction: Approximately one third or more of breast cancer patients will be treated by hormonal therapy (HT). This therapy is not exempt from unwanted side-effects associated with hypoestrogenic state. During hormonal therapy patients can worst their physical symptoms and develop sexual dysfunctions. Objectives: To assess how HT can influence patient’s...
Background:The association of genes involved in detoxification and transport of platinum or taxanes with toxicity may impact an individual patients response to first-line chemotherapy for ovarian carcinoma. Aim: The aim of this study was to evaluate the association between genetic variation in GSTP1 and ABCB1 and toxicities in women with...
Introduction: Lymphomas are divided into non-Hodgkin’s lymphomas and Hodgkin’s lymphomas (HL), based on which classical HL (95% of cases) is characterized based on histopathology through ReedSternberg cells. Hodgkin’s lymphomas survival depends of factors such as age, stage, histological subtype. Overall curability reaches 85%. Due to advances in therapeutics, mortality has...
Case presentation A 70-year old woman presented with acute confusional state. She had been receiving atezolizumab for locally invasive lung adenocarcinoma. Laboratory workup showed no significant abnormalities. Electroencephalogram (EEG) was negative for epileptiform discharges. Brain MRI showed a solitary left occipital brain lesion compatible with brain metastasis, which had been...
Background Febrile neutropenia (FN) is a challenging oncological emergency with potentially serious complications, especially for patients (pts) treated at non-oncological centers. Data on adherence to FN guidelines recommendations at private hospitals as well as clinical outcomes are lacking. Methods We retrospectively reviewed records of all oncologic pts with FN hospitalized...
Introduction: Falls are non planned events occuring by variable multifactorial circumstances that can take the patient to the floor, inflicting lesions or not. In order to evaluate the risk of fall which patients are exposed, there are tools used during institutionalization. Within available scales it is possible to quote the...
The combination of Nivolumab 1mg/kg (NIVO1) plus Ipilimumab 3mg/kg (IPI3) has demonstrated better responses rates and progression free survival compared to NIVO alone in first line treatment of advanced melanoma (Checkmate 067). Recently, NIVO1+IPI3 has shown impressive results in select patients with brain metastasis (Checkmate 204). However, this regimen is...
BACKGROUND Abiraterone acetate (AA) is a potent selective and irreversible inhibitor of CYP17 used as standard treatment for metastatic Castration Resistant Prostate Cancer (mCRPC). In the pivotal trial COU-AA 301, AA 1000 mg/day plus prednisone increased overall survival after docetaxel in patients with mCRPC. A recent trial demonstrated not inferiority...
Background The cancer of unknown primary (CUP) is a heterogeneous group of tumors for which the origin remains unknown despite detailed investigation. Its clinical presentation occurs through metastatic symptoms that may be influenced not only by biological processes of the tumor but also due to regulatory processes in the tumor...
PROGNOSTIC FACTORS OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2- POSITIVE (HER2+) BREAST CANCER PATIENTS WITH BRAIN METASTASIS IN THE ERA OF TARGETED THERAPY
Introduction: Patients with advanced human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) frequently experience brain metastases (BM), which are associated with poor prognosis and thus excluded from most clinical studies. The advent of HER2-directed therapy resulted in improved survival outcomes, and how managing HER2+ BCBM is a challenge...
Introduction: Medication errors with antineoplastic agents have been the subject of publications in several countries and the use of oral anticancer pharmaceutical industry increased over the last 5 years. Based on voluntary notifications in the FDA’s Adverse Event Reporting System errors with antineoplastic corresponded to the second most common cause...
Introduction: A decade ago, sorafenib became the first agent to achieve a survival improvement in patients (pts) with hepatocellular carcinoma (HCC) and remains the cornerstone of systemic therapy. Recently, novel drugs have shown positive results, although they are still not widely available. Clinical trials strictly include pts with preserved liver...
Introduction: Next Generation Sequence (NGS) is an interesting platform which can help clinicians to choose wisely the best treatment for cancer patients according to the presented “drugable mutations.” Objectives: our primary end-point was to analyze the use of NGS tool (Foundation One CDX) to choose the best systemic treatment for...
Case presentation: A.L., male, 59 years old, with history of renal transplantation by amyloidosis in October/2015 and in use of cyclosporine, predinisone, carvedilol and spironolactone. In February 2018 it envolved with a progressive growth nodule on the right hand dorsum and nodule in the right malar region, and was submitted...
Introduction: Despite restrictive criteria for the selection of liver transplant (LT) candidates for hepatocellular carcinoma (HCC), 20% of patients evolve with tumor recurrence (TR), being post-recurrence survival in two years less than 10%. Based on purely structural data, the Milan criteria (MC) are not able to predict the biological behavior...
TNBC treated with NACT followed by surgical resection with curative intent. Methods: We retrospectively analyzed a cohort of breast cancer pts treated with NACT between 2011 and 2018 in an academic cancer center. Electronic records were reviewed for data on clinical and demographic characteristics, treatment and outcomes. Overall survival (OS)...
INEQUALITY AND CANCER IN BRAZIL-INVESTMENT, INSTALLED HEALTH SERVICES CAPACITY AND SOCIAL DEVELOPMENT: A COMPARATIVE ANALYSIS OF THE FACTORS RELATED TO DIFFERENT CANCER OUTCOMES IN THE 26 STATES AND THE FEDERAL DISTRICT OF BRAZIL
Introduction: The incidence and mortality of cancer has been increasing all over the world, this phenomenon has multifactorial causes. Cancer incidence and mortality is influenced by factors as population ageing, life habits, access and quality of health services. This study evaluated the impact of discrepancies of socioeconomic and health assistance...
Background:In addition to the regulation of emotions, serotonin (5-HT) is also responsible for the activation of pathways associated with cell proliferation. The synthesis of 5-HT is dependent on family enzymes tryptophan-hydroxylase (TPH). 5-HT can influence the progression of tumors through the activation of the phosphatidylinositol 3-kinase (PI3K) and serine-threonine kinase...
Introduction: In general, leukemias can be classified as acute or chronic, depending on the compromised cell line. Environmental exposure factors, genetic abnormalities and familial mutations are well established risk factors. In Brazil it is estimated that 10.800 new cases has occurred in 2018, and its been responsible for 6.837 deaths...
Introduction: Desmoid tumors (DT) account for approximately 0.03% of all neoplasms and fewer than 3% of all soft tissue tumors. Although locally aggressive and with a tendency for relapses, DT have no potential for metastasis or dedifferentiation. Most desmoids arise sporadically, and 5-15% of all cases are associated with familial...
Introduction: Worldwide, it is estimated that more than 7 million people die annually as a consequence of cancer. The health Care Networks (RAS) are polyarchic organizations of health service sets, integrated among themselves by a single mission, by common objectives and by a cooperative and interdependent action, which allow the...
Introduction: Everyday use of social media among health professionals is likely increasing for both personal and professional intents. However, such practice can be accompanied by perilous exposure, as conflicts of interest might bias public perception obtained via fast-paced electronic social networks. Here we address conflict of interest disclosures in social...
Introduction: About 30% of early-stage breast cancer patients with hormonal receptor tumors show resistance to tamoxifen during adjuvant treatment, which may result in local or distant recurrence. It is known that the development and aggressiveness of tumors are associated with oxidative stress and antioxidant enzymes such as SOD2. The evaluation...
Objective: To investigate the quality of life of women with breast cancer undergoing chemotherapy. Methods: A cross-sectional study was carried out in a specialized cancer treatment institution. It was applied a questionnaire on quality of life (Quality of Life Questionnaire - Breast Cancer 23), translated and validated for the Portuguese,...
PRACTICE PATTERNS OF PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) RECEIVING TRANSARTERIAL CHEMOEMBOLIZATION (TACE): FINAL ANALYSIS OF OPTIMIS IN LATIN AMERICA
Introduction: OPTIMIS was a global, prospective, noninterventional study evaluating outcomes and practice patterns in patients with HCC treated with TACE, followed or not followed by sorafenib. Using protocolspecified criteria in the global cohort, we have observed longer OS in propensity score matched cohort with early start of sorafenib (16.2 months...
Food plays an essential role in people's lives and its importance does not change with time or with the presence of a disease that threatens life. It is common at the end of life or the presence of intolerance to an artificial diet. There are evidences that artificial feeding can...
Introduction: Alopecia is a stigmatizing adverse event of the patient in chemotherapy, affecting the quality of life, body self-image, sexuality and selfesteem. Its incidence is estimated at more than 60% in the use of alkylating and anti-microtubule agents, 60-100% with topoisomerase inhibitors and 10-50% with antimetabolics, reaching more than 90%...
Introduction: Epidemiological data of neuroendocrine tumors of the gastrointestinal tract (NETGI) in Brazil are poorly understood. The present study aims to describe the profile of NETGI in Brazil using the data available from the Hospital-based Cancer Registries (HCR). Methods: This is a cross-sectional study with data from HCR of Brazil....
Introduction: In the Comprehensive Geriatric Assessment (CGA), polypharmacy is one of the risk factors for death and reduction of overall survival, which supports the need to analyze its effects on the outcomes of older patients with cancer still not well represented in scientific research. Objective: The determination of prevalence of...
Introduction: Gliomas are the most common neoplasms of the Central Nervous System, representing 80% of the primary malignant tumors. Astrocytomas are 66% of the gliomas and have a global incidence 2,98/100.000 habitants. The immunohistochemistry associated with the histopathological analysis, are the main exams to the classification, according to World Health...
