ABSTRACT Objective: Analyze data regarding patients in need of hospital care admitted in our oncology infirmary aiming for better clinical practices, clinical support and scope for financial and structural needs for institutions. Methods: A prospective study of 191 patients admitted for in-hospital care during a year, who were stratified by diagnosis, age,...
ABSTRACT The implementation, current status and future perspectives of the pharmacogenetics/genomics (PGx) testing program developed at Instituto Nacional de Cancer (INCA) are presented. Initial selection of drug-gene pairs for PGx testing was based on clinically-validated PGx associations and availability of international guidelines with PGx-informed dosing recommendations. The selected pairs were...
ABSTRACT Introduction: Standard treatment for pediatric patients with localized osteosarcoma includes high-dose methotrexate (HDMTX), and cure rates greater than 60% are observed. However, in adult patients, the toxicity profile limits the use of HDMTX and the drug is usually excluded from chemotherapy protocols for this group. We aimed to evaluate the...
ABSTRACT Objectives: The COVID-19 infection was declared pandemic in March 2020. Since then, multiple studies have attempted to correlate clinical factors with the risk of complications from COVID-19. However, cancer patients are underrepresented in clinical trials and the results vary between different cohorts. Our goal is to describe a cohort of...
ABSTRACT ATLL is a malignant and aggressive leukemia whose survival time is limited. It is known that 5% of individuals infected with HTLV-1, after many years of latency, may develop this disease. The mechanisms by which the evolution of clinical conditions occurs are unknown, and in Brazil there are few...
ABSTRACT Hemangioendothelioma is a rare vascular tumor whose etiology has not yet been defined. Currently, it is known to affect different sites, such as the abdominal-pelvic cavity. It is also known to present intermediate characteristics to hemangioma and angiosarcoma. In recent studies, 50-76% of patients are asymptomatic. Surgical treatment is...
ABSTRACT Penile melanoma is a rare event, responsible for less than 1.4% of penile cancers. In general, it is late diagnosed and the treatment is usually aggressive. The authors present a 66-year-old Caucasian man who had an ulcerated penile lesion for 1 year, diagnosed as melanoma after biopsy and treated...
ABSTRACT Introduction: Well-differentiated neuroendocrine pulmonary tumours (NETp) are morphologically classified as typical carcinoid (TC) and atypical carcinoid (AC). There are limited data on systemic treatment for metastatic disease. Objective: Our study evaluated the median progression-free survival of patients with metastatic tumours, comparing TC and AC status for different treatments. Methods: Retrospective series...
ABSTRACT The most common sites for metastatic breast neoplasm are the bones, lungs, liver, and central nervous system. Metastases to the gastrointestinal tract are rare and especially involve the stomach, more than to the colon. The clinical and radiological presentation of the metastatic disease usually does not aid in making...
ABSTRACT Introduction: Axillary involvement is one of the main prognostic factors in breast cancer. This study aimed to assess the accuracy of ultrasound-guided fine needle aspiration cytology (US-FNAC) to detect axillary involvement in breast cancer and to compare with other methods of axilla assessment: axillary palpation (AP) and isolated axillary ultrasound...
