To the Editor, In recent years, few studies have provided oncological outcomes with the potential to change clinical practice for patients with cervical cancer, leaving the standard model of combined chemoradiotherapy for locally-advanced disease largely unchanged. Over the past year, 2 phase-III clinical trials—KEYNOTE-A181 and INTERLACE2—have introduced new evidence with...
The present letter focuses on the pharmacogenetic (PGx) testing of variants of the dihydropyrimidine dehydrogenase (DPYD) gene available at Instituto Nacional de Câncer (INCA), Rio de Janeiro, for cancer patients who are candidates for treatment with the fluoropyrimidines 5-fluorouracil (5-FU) and/or capecitabine.1 The rationale for DPYD genotyping is as follows:...
ABSTRACT Objective: This article describes the development process and summarizes the results of the Brazilian physical activity recommendations for cancer prevention and control, which was prepared to support health-care professionals. Material and Methods: These recommendations were elaborated considering: (i) the effect of physical activity on cancer prevention in the general healthy population;...
ABSTRACT The most common sites for metastatic breast neoplasm are the bones, lungs, liver, and central nervous system. Metastases to the gastrointestinal tract are rare and especially involve the stomach, more than to the colon. The clinical and radiological presentation of the metastatic disease usually does not aid in making...
ABSTRACT Cervical cancer is the second most common cancer among women worldwide and also in Angola. Its highest incidence occurs in women between 45 and 55 years of age; the main etymological factor is the infection with human papilloma virus (HPV), whose DNA is detectable in more than 99% of...
ABSTRACT The COVID-19 pandemic threatens to affect head and neck cancer treatment in Brazil. Concerned with the outcomes impact of these aggressive cancer, The Brazilian Society of Surgical Oncology developed recommendations on head and neck cancer management during the outbreak.
ABSTRACT Radiation therapy (RT) uses high doses of high energy X-rays to kill cancer cells. Fractionation and volume optimization were the main methods used to increase the dose given to the tumor and reduce the dose and side effects to the normal tissues (NT). Conventional RT works with dose rates...
ABSTRACT The current pandemic moment of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) has completely changed health services, with most services being directed to the treatment of affected patients. Even during this critical period, cancer patients need to be treated, as delayed treatment can compromise the chances of a cure....
ABSTRACT Concerned with the evolution of COVID-19 in Brazil and its impact on our health system and oncology surgical assistance, the authors performed a review and suggested strategies for approach based on current evidence.
ABSTRACT In December 2019, a novel coronavirus disease (COVID-19) emerged in Wuhan, a city in the Hubei, Province of China. It rapidly spread in an epidemic fashion throughout China, followed by rapid increasing number of cases in many countries throughout the world, including Brazil. It is expected that oncologic patients...
