ABSTRACT Introduction: Older adults require attention to risks of treatment toxicity. The purpose of this study was to evaluate epidemiological data and clinical outcomes of patients with lung cancer treated with non-curative intent assessed by geriatric assessment (GA) and restricted access to new therapies. Methods: We evaluated older adults with non-small cell...
Analysis on complete pathological response and estimated survival among breast cancer patients undergoing neoadjuvant chemotherapy in a private institution in the state of Rio de Janeiro
ABSTRACT Objective: Breast cancer is the most common malignancy among women, both in developed and in developing countries. Indications for neoadjuvant treatment have been expanded so that pathological responses can be evaluated. Diversified therapeutic approaches may thus be indicated in accordance with each residual disease profile. This was a real-life study,...
ABSTRACT Colorectal cancer (CRC) holds third place in the global ranking of malignancies worldwide. Patients with CRC commonly show distinct outcomes and treatment responses due to their biological features and tumoral biomarkers. This review explores the repertoire of molecular biomarkers in CRC, comprised of chromosomal aberrations and genomic instability and...
ABSTRACT Introduction: Ovarian cancer (OC) is one of the leading causes of women's cancer deaths worldwide. Recent clinical trials with PARP inhibitors showed promising therapeutic opportunities for OC patients. The assessment of BRCA mutation is well established as relevant in the prevention, early diagnostic, and family counseling for OC, and recently...
ABSTRACT Papillary carcinoma of the thyroglossal cyst is clinically like the benign lesion in adults aged 15-45 year, with a higher incidence in females. It is a congenital anomaly of the midline of the neck and have the clinical worsening related to infections of high aerodigestive routes. We discuss clinical...
ABSTRACT Emerging data postulates that cancer is an important risk factor for disease severity and higher in-hospital mortality amongst patients with COVID-19. From a pathophysiological perspective, COVID-19 induces an overproduction of inflammatory cytokines, causing systemic inflammation, hypercoagulability, and multiple organ dysfunction syndrome. The exact pathophysiological mechanisms associated with severe COVID-19...
ABSTRACT Introduction: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood. However, primary bone rhabdomyosarcoma is a rare entity with some few cases reported. Case Report: We present a case of a 19-year-old female patient referred from another service with three months history of a bone tumor on the femur. The...
ABSTRACT There has been a rapid increase in the volume of genomic data gathered from different cancers, this has helped to develop new tumor classifications as well as to select better tailored therapies for the patients. Some of the genomic markers identified are also prognostic and predictive factors. Additionally, many...
ABSTRACT Objective: To document the role of physiotherapy in the context of palliative care in cancer through an integrative literature review, as the prevalence and survival of cancer are increasing and physiotherapy can significantly contribute to the treatment of these patients. Methods: A search was made in the literature for scientific articles...
ABSTRACT Targeted and immunotherapy have revolutionized cancer treatment. They safely substitute for traditional chemotherapy in a significant and growing number of malignancies. In this article, we review the United States Food and Drug Administration (FDA) - approved targeted and immunotherapies, currently used in oncology and compare their safety and efficacy...
