CLINICAL AND EPIDEMILOGIAL ANALYSIS OF PATIENTS WITH DESMOID TUMORS: A BRAZILIAN CANCER CENTER RETROSPECTIVE STUDY

Introduction: Desmoid tumors (DT) are rare neoplasms with no potential of distant metastasis but with recognized local aggressiveness due to high recurrence rates. Treatment involves systemic treatment, radiation therapy and surgery. The incidence is predominant in young women. There are no consistent data on incidence, prevalence and types of treatment adopted in Brazilian centers. Objectives: Clinical and epidemiological evaluation of patients diagnosed with desmoid tumor in Brazilian oncology centers. Methodology: observational, retrospective, multicenter study. The study was conducted at the ACCamargo Cancer Center (coordinating center) and participating centers. Clinical and epidemiological information were collected from the patient’s medical record and cataloged in a standardized form (RedCap). The variables that were analyzed were age, sex, family history, pre-treatment and type of biopsy, initial treatment, recurrence. Statistical analysis: descriptive analysis of the variables was carried out, absolute (n) and relative (%) frequency were obtained. To assess the association between qualitative variables, the chi-square test or Fisher’s exact test was used. Result: The population of this study was 242 medical records of patients with desmoid tumor. The mean age was 34 years (1-82 years). Out of 242 pts, 54.1 were white, 70.7% were female and 74.0% had medical insurance, 59.9% had symptoms of mass/increase in volume, 73.6% had locoregional disease, most had tumor located in trunk/abdomen, 52.1% had primary tumors < 5 cm. Surgery as first treatment occurred in 70.2%, folllowed by systemic therapy (10%) and 57.0% had a previous biopsy, 31.0% of participants had negative margins. Relapse was observed in 29.3% and 52% were treated with surgery followed by systemic therapy (16%) Conclusion: We present data from the clinical and epidemiological study of desmoid tumors, through hospital epidemiological analysis. We obsreved that surgery was the most frequent upfront treatment and was the mais rescue treatment for relapse. These findings are in contrast with the most recent recommended approach to desmoid tumor. These data can guide adjustments in treatment recommendations and follow-up of patients diagnosed with desmoid tumor.