THE POSSIBLE INFLUENCE OF ANGPTLS INHIBITORY RECEPTORS IN LEUKEMIC BLOOD CELLS AND THE DEVELOPMENT OF GLAUCOMAS

Introduction: In 40 years, several studies on the development of ophthalmological pathologies, including glaucomas, have been carried out in patients with leukemia. Statistics show that even underdiagnosed and varying from 2 – 3% among older studies, the frequency of open and closed angle glaucoma in leukemic patients in both children and adults is extremely high when compared to the non-leukemic group, reaching 0.0000229% in children. Aims: The objective of this article is to relate the known mutations in angiopoietin inhibitory receptors (ANGPTLs). Which recent discoveries related those with the development of glaucoma. In addiction were evaluated possible relationship between ANGPTL2 with open-angle glaucoma and ANGPTL7 receptors with for closed angle glaucomas, with accelerated development of leukemic glaucoma. Methods: PUBMED and EMBASE were used for selecting the reviewed article. Texts related to functionality changes of ANGPTLs in leukemics and in the glaucoma formation were integrated to support this theory. The objective of this study was to evaluate possible association between leukemic in children and premature development glaucomas, favoring the evidence of molecular alterations related to ANGPTLs. Results: The high affinity interaction of hyperexpressed LILR2B2 inhibitory receptors found in leukemic blood cells with their ligand ANGPTL2 and the low affinity to Tie2 receptors also found in Schlemm’s endothelium may possibly favor the deprivation of this relation pathway, which is responsible for maintaining their opening and its progressive occlusion, forming open-angle glaucoma. ANGPTL7, in parallel, has low affinity for its hyperexpressed LAIR1 receptors. What can may favor the non-adhesion of these proteins to circulating cells, which leads to their accumulation in regions of greater affinity, such as in the trabecular meshwork in the anterior chambers of the eyes, thereby modulating the dysfunction of those and developing closed-angle glaucomas. Conclusion: The aim of this review was to evaluate the possibility of a relationship between inhibitory receptors of ANGPTLs in leukemics with their respective ligands ANGPTLs 2 and 7 and the frequent development of glaucomas in this group of patients, in order to offer perspective for future treatments for these secondary pathology decreasing their comorbidities.