PROFILE OF PHARMACEUTICAL INTERVENTIONS IN PRESCRIPTIONS OF ANTINEOPLASTIC PROTOCOLS AND MEDICAL ACCEPTANCE: MULTIPROFESSIONAL WORK ON PATIENT SECURITY

Introduction: Pharmaceutical intervention is the planned and documented pharmaceutical act for the purpose of preventing or solving problems related to pharmacotherapy and can be performed with the user and other health professionals. Objective: Report of the experience of evaluation and validation of the medical prescription by the Clinical Pharmacy of a Private Oncology Service of João Pessoa – PB during the period from June 2018 to June 2019. Methods: The medical prescriptions of antineoplastic protocols are sent to the clinical pharmacist for evaluation and validation, after which it is to be dispensed by the pharmacy and then handled. When evaluating the prescription, the pharmacist checks the patient’s data, name, date of birth, CID, and protocol, doses, cycle day, number of cycles performed and how the drugs were authorized by the agreement or payment. When finding items in disagreement with the expected or some error of prescription, the prescription is forwarded to the prescriber with due justification and this examines the pertinence of the pharmaceutical intervention, accepting it and correcting the prescription or refusing it under medical justification. Results: During the study period, 10042 prescriptions were issued, 100% of which were evaluated by clinical pharmacists, generating a total of 351 interventions with an acceptance rate of 99.4% (n=349). The main interventions were dose adjustment, 38.7% (n = 136) of total, inclusion of medication, 22.5% (n=79), adequacy of diluent volume 10.5% (n=37), medication replacement (n=36), medication suspension (n= 36), medication suspension 8.8% (n=31), suitability for treatment day or cycle 3.7% (n=13). The interventions for dose adjustment, mostly, are related to the reduction by toxicity that was not perceived by the attending physician. Drug replacement or inclusion interventions were related to patients who had infusion reactions to chemotherapy and required supportive medications or who had an allergic reaction to a prescription drug that could be replaced. Conclusion: The level of acceptance by the prescribing of pharmaceutical interventions was high, which altered or generated new prescriptions, allowing patients to receive their protocols more safely and correctly, without burden to the service or to the patient. In this way the continuous multiprofessional work contributed directly to the safety culture of the patient.